Sentences with phrase «knockout mice»

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

However, the magnitude of these behavioral responses in knockout mice was 40 % lower than in wild - type mice.

We use what are called conditional knockout mice, in which a gene is deleted only in a specific organ or group of cells.

I started this project with no personal experience in creating knockout mice.

Therefore, it becomes possible to improve the efficiency of collecting, preserving and providing knockout mouse.

Researchers make knockout mice by disrupting the function of individual genes across the animal's genome.

The first knockout mice constructed by gene targeting were published in 1989, and the rest is history.

These genetic modification techniques debuted in the 1980s, but the first autism knockout mice took a while longer to develop, emerging only in the early 2000s.

There is a new contender in the field of gene discovery, and it's giving knockout mice a run for their money.

A new study suggests that they do, and that they should take it into account in experiments involving knockout mice.

The Study: The group specifically targets studies that utilize knockout mice, a technique developed in the late 1980s in which strains of mice are bred with specific genes turned off.

We are pleased to contribute to this international effort establishing a global resource of knockout mice and related database of gene function.

Her doctoral work with Dr. Virginia Smith Shapiro focused on elucidating the role of transcription regulators (NKAP, HDAC3 and Runx1) in T cell maturation using conditional knockout mouse models and multi-color flow cytometry, and identifying novel mechanisms such as complement and sialylation that monitor the maturity of recent thymic emigrants.

The insulin - receptor knockout mice developed cholesterol plaques that were more than twice the size of those found in the control animals.

In doing so, the researchers could accomplish in a few years for a tiny fraction of the cost what the International Knockout Mouse Consortium will accomplish in 10 years, at a cost of nearly $ 1 billion, he said.

Nadia Nabil Haj - Yasein Roles of aquaporin 4 and Kir4.1 in brain water and potassium homeostasis: lessons from knockout mice Faculty of Medicine, University of Oslo, 28 February 2012 Supervisor: Erlend Arnulf Nagelhus

Baker, K.; Wray, S.; Ritter, R.; Mason, S.; Lanthorn, T.; Savelieva, K. Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments.

We generated knockout mice lacking synaptobrevin / VAMP 2, the vesicular SNARE protein responsible for synaptic vesicle fusion in forebrain synapses, to make use of the exquisite temporal resolution of electrophysiology in measuring fusion.

That would amplify a trend that began about 15 years ago when knockout mice first became common.

Now that they have a FAN1 knockout mouse in hand, and they have confirmed that it mimics many aspects of karyomegalic interstitial nephritis in humans, Smogorzewska's lab can start to delve into how the loss of the gene causes kidney degeneration.

Both behavioral and physiological experiments revealed that the Ggamma13 knockout mice did not respond to odors.

«With our newly developed method, it is possible to reduce the number of female knockout mice used in egg collection by 1/3 — 1/4 or less.»

As expected, gp96 knockout mice grew normally at first.

The relationship between parietal cell function and achlorhydria is illustrated using genetic knockout mice models, as follows:

In this study, by using a systemic mtEF4 gene knockout mouse model, researchers found that mtEF4 knockout damages the oxidative phosphorylation function in germ cells of male mice, thus causing male sterility.

This corroborated with the absence of Slc6a14 protein in colon and lung from knockout mice as evident from immunofluorescence (Figure 1B).

El - Khodor, B. F.; Dimmler, M. H.; Amara, D. A.; Hofer, M.; Hen, R.; Brunner, D. Juvenile 5HT (1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT (1A) receptor activation.

If the GH knockout Mice lived longer when being given exogenous GH would that be evidence of another, poorly understood receptor for GH?

«Knockout mouse grows larger, but weaker, muscles.»

And when the team examined the brain tissue of the homozygous knockout mice, it found striking developmental abnormalities in the cerebellum, especially in the Purkinje cells, which are involved in fine motor control.

Responses from the Ggamma13 knockout mice were greatly reduced, suggesting that the olfactory receptors of these mice were unable to translate odor signals into an electrical response.

Eliminating genes in mice is a standard technique for determining their function; the resultant animals are called knockout mice.

In addition, the researchers reported that MMP - 3 induced blood cell infiltration and hemorrhage after SCI in wild - type mice, but not in Mmp3 knockout mice.

Western Diet — Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment — Prasant K — The American Journal of Pathology

To explore the impact of such smooth muscle defects on cardiac function, the scientists exercised δ - sarcoglycan knockout mice on treadmills.

which would live longer given supplemental GH, the GH knockout mice or the GH deficient mice?

Closer study of the Ro - knockout mice revealed that they had kidney lesions similar to those observed in patients with lupus.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.