Sentences with word «allele»

Evolution the fact is defined as a change in allele frequency in a population over time.

Today, evolution is defined as the change in the frequency of alleles in populations over time.

Importantly, we also reveal a novel and surprising negative association between individualism — collectivism, frequency of S allele carriers of the serotonin transporter gene and global prevalence of anxiety and mood disorder.

Use of common risk alleles for changes in clinical management can be challenging without a professional guideline.

The randomized study reveals a current 2 % PFK mutant allele frequency in the field trial ESSP breeding population.

Data Extraction Logistic regression was used to estimate the effects of the number of short alleles at 5 - HTTLPR, the number of stressful life events, and their interaction on depression.

The impact of a common risk allele with disease risk is often modest, as is its impact on clinical care.

While this calling method will inevitably miss variants in low coverage individuals, the relative numbers of shared alleles with different populations is unbiased.

My family history doesn't have much in the way of rare inherited syndromes, but that doesn't mean I'm not a carrier of one or two recessive alleles for something like cystic fibrosis.

(F) The sequence of eight mutant alleles from quadruple - mutant colonies # 5, # 45 and # 79.

The dog's color can vary greatly with different mutated alleles on other genes.

In particular, exposure to chronic life stress, such as interpersonal conflict, loss or threat, is considered a well - known environmental risk factor for depression in S allele carriers of the 5 - HTT (Caspi et al. 2003; see also Risch et al. 2009).

A further investigation of the DRD4 48 bp VNTR showed that infant genotype moderated the previously reported intergenerational transmission of mothers» unresolved trauma to disorganised attachment: the link was significant for infants carrying the 7 - repeat allele only [105].

Not so long ago, there was a hope in the research community that common genetic variation, i.e. variants present at minor allele frequencies > 5 % in human populations, might explain most or all of the heritability of common complex disease.

Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP - 25, and 5HT1B

Other groups have found heightened sensitivity to positive social influences amongst short allele carriers as well, which has even been documented using neurochemical measures (Manuck et al., 2004).

This social construction of the self may function akin to an implicit social support network (Kim et al., 2008) that is likely to buffer individuals with social sensitivity alleles from the adverse consequences of stress and improve life satisfaction.

Importantly, analysis of blood samples from 99 healthy individuals showed that the G allele at rs9349379 is associated with higher levels of Big endothelin - 1 (ET - 1), a precursor protein product of the EDN1 gene.

Making it more complicated, in order to have E express itself as a black coat, it is necessary to also have the As allele for self - or solid - black at the A locus.

These dogs are very likely to develop PRA associated with the IG - PRA1 risk allele by the time they reach 5 - 7 years of age.

Interestingly, certain allelic combinations give rise to embryos that arrest early in development, while other alleles complement female sterility of the rum mutation.

Besides ensuring correct chromosome segregation during the first meiotic division, crossovers create new allele combinations in gametes, thereby increasing genomic diversity, increasing the chance of creating offsprings with better phenotypic fitness, and providing the basis for faster evolution.

In this way, the study of mutations has been of inestimable value in the field of genetics, leading for instance to a knowledge of the multiple alleles which is of far - reaching importance in human pathology, and to the experimental production of artificial mutates.

As a central repository for variant allele frequency (VAF) data, dbSNP can be a powerful resource for human genetics studies.

Again, the increased activity in these areas was associated with the number of copies of the A allele carried by individuals — people with two copies showed a larger increase in activity than those with just one.

In Dunedin, breastfed children carrying the C allele showed a 6.4 - IQ - point advantage relative to children not fed breast milk (t = 6.35, P < 0.001).

At low - density lipoprotein receptor (LDLR), carriers of rare non-synonymous mutations were at 4.2-fold increased risk for MI; carriers of null alleles at LDLR were at even higher risk (13-fold difference).

Many brachycephalic or «smushed face» breeds such as the English Bulldog, Pug, and Pekingese have two copies of the derived A allele.

In this scenario, if a locus i contains a drive element and the next locus does not, then the drive cuts both wild - type alleles at that locus until both copies are disrupted, rendering resulting gametes nonviable (ci = 1).

The most dominant allele will not produce mask or yellow, so dogs that have one copy will have coat color determined by other genes.

However, several additional psq alleles show distinct embryonic or adult phenotypes.

The dogs that lack the specific dominant E allele for those dark coats will have hair limited to the various shades of red / tan / fawn («yellow»).

That would mean that both the Sire and the Dam would have to contribute a recessive b allele on to the puppy in order for it to be a Chocolate Labrador.

(D) DNA sequence of mutated alleles from MSTN / PrP double - mutant colony # 32 and # 40.

If the puppy has a recessive d allele passed on from both parents, they will have the «dilute gene» activated.

Fourteen of the 16 mutant alleles identified were previously unknown.