Sentences with phrase «expression levels»
"Expression levels" refers to the amounts or levels at which something (such as a gene or protein) is being expressed or produced in a living organism. It indicates how active or strong a specific biological process is within the organism's cells. Full definition
Results showed increased expression levels of genes associated with drug transport in kidney tissues in the evening hours than in the morning hours.
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This can then be used to create computational estimates of gene expression levels from any whole genome sequence or chip dataset.
In fact, five of the 100 most stable genes have altered expression levels in liver cancer.
This assumes all the marker genes have independently increased expression level for their respective cell type.
When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.
To determine expression levels, in traditional sequencing methods a mix of millions of cells is used.
Identifying adaptive and plastic gene expression levels using a unified model for expression variance between and within species.
A web - based tool in which users can upload their individual SNP data and obtain predicted expression levels for the set of predictable genes across the 14 different cell types.
The parameter \ (l \) describes the scale at which expression levels are locally similar.
These changes in expression levels allow the bacteria to alter their composition to better survive stress.
We show, for the first time, the influence of the gene expression levels demonstrating the power of «big data» to change how medical research is performed.
Thus, ratios of 1.0 indicate that expression levels in the two regions are comparable.
Many human traits — from gene expression levels to disease risk — vary between individuals.
High mRNA expression levels of HNF4α and ASGPR1 are shown in the enhanced hiPS - HEP cells for an extended culture time and are comparable to levels in cryopreserved human primary hepatocytes (hphep cells) that have been grown for only a short time.
Although it is possible to drive co-expression by using a plasmid with multiple, individual expression cassettes, having the genes expressed from the same cassette is sometimes advantageous, particularly when only a portion of the plasmid is packaged for viral delivery, or the relative expression levels between two or more genes is important.
Sex ratio was based on expression levels of Sox9 and all data were tested for normality and for homogeneity before statistical analysis.
Protein expression levels of DDX3 analyzed by immunohistochemical staining are also subjected to similar classification (see Materials and Methods).
Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.
Then, using microarray chips, they measured expression levels of those genes.
«We didn't know before these results came out that there are a large number of genes with expression levels systematically different between mouse and human,» said Ross Hardison, Ph.D., director, Huck Institute for Comparative Genomics and Bioinformatics at Pennsylvania State University, University Park, and a co-senior author on the main Nature study and other publications.
These gene expression data provide a sex - and tissue - specific correlation between dsx expression level and wing size.
In some cases affected transcripts in Cre +; Tsc1 flox / flox mice showed significant variation among individuals that can not simply be explained by differential effectiveness of CRE - mediated knockout since, except one animal, all Cre +; Tsc1 flox / flox mice showed similarly reduced expression levels of Tsc1 mRNA.
Pair-wise comparisons (FDR < 0.05, > 1.5-fold expression levels) were performed between the following populations of cells to reveal non-redundant, significant changes in gene expression.
Optimize protocols for culturing and maintaining Hela cells, identifying and characterizing proteins, enrichment of integral membrane proteins from mammalian tissue, biotinylation and isolation of mammalian cell surface proteins, and isotope metabolic protein labeling, quantization of protein expression levels from differentially treated cell populations.
Despite having tightly controlled expression levels, little is known about how miRNAs themselves are regulated because their genes are poorly defined.
This increased protein synthesis, or translation, can be traced back to elevated expression levels of RNA polymerase I, a macromolecular assembly that produces a major component of the translational machinery.
found increased expression levels of genes that are considered to be associated with AD (BACE2, RCAN1, ETS2, TMED10), as compared to healthy controls.
These studies are unable to determine a causal relationship due to factors such as gene regulation — a genetic variant may instead contribute to altered expression levels of true causal genes, which remain undetected by a GWAS.
Following purification, recombinant proteins were quantitated by ELISA and while expression levels varied significantly between individual proteins, most were purified to micromolar levels (Table 1).
Examining expression levels of H2AX in breast cancer tumor data from The Cancer Genome Atlas, a large National Institutes of Health database containing genetic information about tumor tissue from more than 11,000 patients, the Roswell Park team found that breast cancer patients whose tumors had high levels of H2AX had a significantly worse prognosis than those with low levels.
In fact, p73 expression may not always be related to p53 expression levels as p73 has properties independent of p53 [45].
The Clock mutants were also shown to exhibit reduced overall expression levels and a blunted diurnal rhythm of orexin mRNA, a hypothalamic neuropeptide involved in energy regulation (2).
The SpatialDE test fits the \ (\ sigma ^ 2 \) and \ (\ delta \) parameters to each genes observed expression levels, and also compares the likelihood with a model that has no spatial variance (FSV = 0) to obtain a significance level (p - value).
«exerted numerous adverse effects, including reduction in beneficial decal microflora, increased fecal pH, and enhanced expression levels of p - gp»
Researchers also found that Ex-miRNA expression level changes seem more specific to disease states than the measure of miRNA from plasma without attention to the isolation of Ex-miRNA, suggesting that Ex-miRNA may offer an approach that improves current methods of monitoring patients with heart disease, yet relies on readily available samples such as blood and urine, according to the study.
The log10 FPKM +1 values from the RNAseq data are plotted in blue, and genes are ordered by decreasing expression level.