Sentences with word «subunit»

It is not known whether coordination in the expression of subunits of essential complexes occurs at the level of transcription, mRNA abundance or protein expression.

The simulations demonstrated that the critical factor is particle density — in other words, the total concentration of subunits in the system: In a system in which the particle density is low, opportunities for interaction are few, and individual filaments are widely separated.

This block is caused by mutations of the gene encoding the γc cytokine receptor subunit of interleukin - 2, -4, -7, -9, and -15 receptors, which participates in the delivery of growth, survival, and differentiation signals to early lymphoid progenitors.

An antibody to a peptide synthesized according to deduced amino acid sequence reacts specifically with the alpha subunit of Gs.

Catalytic protein subunits of telomerase from the ciliateEuplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs.

We will also assess whether the findings can be translated to a model of lethal murine malaria using Clone 10 - homologue DNA and protein subunit vaccines derived from Plasmodium berghei (ANKA) to induce immunity.

Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin, have been solved at between 3.1 and 3.3 angstroms resolution.

In fact, rare individuals missing the beta subunit genes produce only fetal hemoglobin throughout their lives and are perfectly normal, says study leader Stuart Orkin, a hematologist at Children's Hospital Boston.

The phylogeny of Myxosporea (Myxozoa) based on small subunit ribosomal RNA gene analysis.

While SIRT1 and 2 inhibit NF - kB through posttranslational modification, SIRT6 neutralizes it by decreasing the accessibility of p65 subunit on promoter region of NF - kB target genes 32.

Evidence suggests that both alpha and beta gamma subunits of heterotrimeric guanine nucleotide - binding regulatory proteins (G proteins) inhibit adenylyl cyclase.

Phylogenetic analysis of the non-pathogenic genus Spiromastix (Onygenaceae) and related onygenalean taxa based on large subunit ribosomal DNA sequences.

Analysis of crosslinked complexes of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli, and transfer RNA precursor substrates has led to the identification of regions in the enzyme and in the substrate that are in close physical proximity to each other.

Adjuvants are especially necessary to boost the immune response for subunit vaccines.

«It becomes clear that these two complexes are not only structurally and functionally similar,» says Elena Conti, «also their regulatory subunits work in a similar manner.»

Expression of the α3, α4, and α7 nAChR subunits in cerebellar cultured cells was examined by RT - PCR.

In the new study, experiments with genetically modified C. trachomatis and host cell lines showed that a C. trachomatis protein found in the inclusion membrane, myosin regulatory complex subunit A (MrcA), interacts with the host proteins ITPR3 and STIM1.

Each c subunit forms an α - helical hairpin.

With just 121 genes (compared with humans» 20,000 to 25,000), the Tremblaya genome is the smallest ever found in an organism that isn't an organelle, a small subunit within a cell that has a little bit of its own DNA.

Four identical subunits make up the antiviral SAMHD1 enzyme.

The CHRNA5 - CHRNA3 - CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African — Americans and in European — Americans

In contrast, the retrograde transport of the Shiga toxin B subunit between the plasma membrane and the Golgi complex is partly inhibited in cells overexpressing the Rab6 - binding domain of Rab6IP2.

The structure shows that an exposed surface of DNA - bound TAP, called AR4, makes protein to protein contacts with the RNA polymerase α subunit C - terminal domain.

We found that genes encoding subunits of the Mg - chelatase complex and 3,8 - divinyl protochlorophyllide a 8 - vinyl reductase (DVR) likely function directly downstream of the GATAs and that DVR expression is limiting in the pale - green gnc gnl mutants.

Each curli fiber is made from a repeating chain of identical protein subunits called CsgA, which can be modified by adding protein fragments called peptides.

Vaccines made of protein or sugar fragments, also known as subunit vaccines, have been successful against a few diseases, such as hepatitis and diphtheria.

Pol III is pretty complicated — it is made up of 17 different subunits encoded by 17 different essential genes.

Craig Venter «s team at the J. Craig Venter Institute in Rockville, Maryland, and San Diego, California, has made a bacterial genome from smaller DNA subunits and then transplanted the whole thing into another cell.

Day, D.E., Cooper, M.A., Markham, C.M., and Huhman, K.L. NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters.

«From this we observed which subunit within TORC2 was obstructing the rapamycin - binding site on TOR.»

A2 integrin subunit cytoplasmic domain dependent cellular migration requiresp38 MAPK.

The SMARCA4 encodes a catalytic ATPase subunit of the SWI / SNF chromatin remodeling complex.

Two tandem C - terminal regulator of K + conductance (RCK) domains from each of four channel subunits form a 350 - kilodalton gating ring at the intracellular membrane surface.

This protein in turn interacts with both PKA and PP2B (Protein Kinase A and Protein Phosphatase 2B; (College et al 2000, Tavalin et al 2002)-RRB- that between them control the phosphorylation state of Ser845 on the GluA1 subunit.

Suppressing the expression of even one of the many subunits making up the cap will impair the assembly of the whole cap, resulting in a proteasome - inhibitor resistant state.

This finding — which also identifies a biomarker that can be used to gain a deeper understanding of the proteasome inhibitor - resistant state — is reported in the Proceedings of the National Academy of Sciences (PNAS) in an article entitled, Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.

These differences correlated with the observation that the B - subunit associated with Triton X-100-resistant membranes in HeLa cells, but not in monocyte - derived cells, suggesting that retrograde targeting to the biosynthetic / secretory pathway required association with specialized microdomains of biological membranes.

One year later, the same investigators, in collaboration with Rita Balice - Gordon, PhD, professor of Neuroscience, characterized the main syndrome and provided preliminary evidence that the antibodies have a pathogenic effect on the NR1 subunit of the NMDA receptor in the Lancet Neurology in December 2008.

Its wall is made up of 13 protofilaments, each consisting of heterodimeric subunits containing two related tubulin proteins.

Cryo — electron microscopy of the ribosome - Sec61 complex and a three - dimensional reconstruction showed that the Sec61 oligomer is attached to the large ribosomal subunit by a single connection.

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

HIPK2 - Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death

NF - kB / p65 subunit DNA - interaction increase with increase of age in several tissues suggesting as NF - kB inhibition may prevent aging and its related diseases 25.

General transcription factor TFIIH plays central roles in gene transcription and DNA repair ISB researchers and collaborators map the architecture of the TFIIH complex using powerful crosslinking - mass spectrometry (CXMS) technology and integrative modeling Structural maps provide critical insights into how mutations in TFIIH subunits lead to disease phenotypes By Jie Luo and Mark Gillespie The expression, or transcription, of genes controls the identity and function of a cell.

Presenilin - 1 (PS1) or presenilin - 2 (PS2), nicastrin (NCT), anterior pharynx - defective 1 (Aph - 1), and presenilin enhancer - 2 (Pen - 2) have been considered the minimal essential subunits required to form an active γ - secretase complex.