Sentences with phrase «of a single gene»

They asked the question, What controls the activity of a single gene, turning it on or off?

It can take up to a year to determine the function of a single gene, which has slowed efforts to develop new, more targeted drugs and vaccines.

Five to 10 years ago, the sequencing of a single gene was often sufficient to get a scientist's work published in a prestigious journal.

One of the most basic misconceptions in biology education is the notion that a trait is the product of a single gene.

But now, with the addition of a single gene, rice can be cultivated to emit virtually no methane.

The mutant rodents represent a rare case of a single gene substantially influencing life span in mammals.

That photograph impressed on him the potentially immense power of a single gene.

Users can enter the name of a single gene or lists of many genes to retrieve drugs targeting those genes.

Changes in the regulatory region of a single gene may have had a profound affect on human evolution.

Teasing out the effect of single genes in deafness is difficult.

That pattern of inheritance would suggest the strong effect of a single gene mutation, and it would most likely crop up in families that had a lot of shared genes through the intermarriage of first cousins.

Part of what makes them that way is the mutation of a single gene called insulin - like growth factor 1 (IGF1), according to a group of researchers from the University of Utah, Cornell University, and the National Human Genome Research Institute.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

The unintended consequence of a single gene change pale in comparison to the negative health consequences of the intensive inbreeding required to produce the extreme physical features of the fad breeds of today.

Huntington's disease is caused by a mutant form of a single gene called Huntingtin.

With the data provided by the FLI researchers, scientists around the world may now set targeted mutations to investigate the relevance of single genes for aging, in order to better understand regulating mechanisms and, eventually, develop new approaches for therapy or prevention of aging - related diseases.

A massive genetics study relying on MRI brain scans and DNA samples from over 20,000 people has revealed what is claimed as the biggest effect yet of a single gene on intelligence — although the effect is small.

An article in New Scientist (12 May 2012) explored the fact that a double mutation of a single gene seems to have taken place about 2.5 million years ago, beginning the separation of homo from Australopithecus.

We know that in general this control of complex development processes takes place earlier than the control of single genes, but I doubt whether we know any more about it now than we did when I first formulated it, around 1940.

The results of the study were obtained by infecting laboratory - grown cells with forms of the CMV virus which differed only by the removal of a single gene.

According to study co-author Larry J. Young of Emory University, the results provide evidence in a comparatively simple animal model that changes in the activity of a single gene profoundly can change a fundamental social behavior of animals within a species.

Results from a statistical analysis shows a cluster of SNPs — single nucleotide polymorphisms — in one section of a single gene, indicating the location of a mutation likely linked to autism.

«For species that have a very rapidly changing environment, this process of co-option of single genes may be fairly important.

The study, published in Nature Genetics, offers the possibility that targeting these processes, instead of single genes, may provide new opportunities for treatment of Wilms tumor.

«But it's remarkable that lowering levels of a single gene could have such a strong effect on the disease.

This means that evolution of a single gene can rapidly lead to differences within a species, says Loudet.

And although doctors use genetic screening to identify versions of single genes known to cause diseases like cystic fibrosis, other conditions such as blindness can be caused by mutations in many genes.

Now, a study led by a researcher at the Salk Institute has found that variants of a single gene can largely determine a plant's ability to thrive in environments where iron is scarce.

«So, the flexibility of yeast cells does not arise from the activity or inactivity of a single gene,» project head at ISB, Dr. Aimée Dudley, explains.

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to begin a chain reaction and become abnormal, according to research by Queen Mary University of London (QMUL).

Instead of the simple manipulation of single genes, he wants to engineer many genes to work together, like transistors wired in a circuit.

Thus I was able to ask how the expression of this single gene limits the size of the haltere.

But an alternative explanation is that inheriting recessive copies of a single gene from both parents often, but not always, causes the disorder.

First, unlike CRISPR, the AAV - based approach is only able to target a single allele of a single gene at once.

Around 2.5 million years ago, the erroneous duplication of a single gene changed the course of our brains» evolution forever.

Single gene PDG: Helping carriers of single gene disorders have a successful pregnancy and a healthy baby.

While his previous method relied almost entirely on small molecules, it still included a minute amount of genetic manipulation; that is, he often required the use of a single gene to enhance his chemical cocktails.

Systems biology uses a variety of omics tools including genomics, bioinformatics, metabolomics and proteomics to understand biology at a high level of complexity, such as how mutation or loss of a single gene affects cells, tissues and even the entire organism.

Conditional expression of hairpin constructs in Drosophila is a powerful method to disrupt the activity of single genes with a spatial and temporal resolution that is impossible, or exceedingly difficult, using classical genetic methods.

By getting back to basics, they reasoned, scientists might stand a chance of actually understanding the purpose of every single gene in a living cell.

All with the snip of a single gene.

Such models aim to elucidate the contribution of single genes for protection against mutations, genomic instability, ageing and ageing related diseases such as cancer.

There is ample evidence of the harm done by popular sire breeding and doing so based on the status of a single gene is especially risky.

Piebald colouring is normally a result of a single gene mutation.

That view of eukaryote evolution based on analysis of a single gene «was in textbooks, and it was what many people had made their careers on,» he says.

That is easy to explain by a feature that we now recognize as universal: the plasticity of expression of single genes.

The transition from basic research to the commercialisation of scientific ideas and discoveries is not an obvious one for those who have spent years in a university lab investigating the function of a single gene or a particular step in a biochemical pathway.