Sentences with phrase «cell lineages»
The phrase "cell lineages" refers to the series of cells that are related and come from a single parent cell. It shows how cells divide and differentiate into specialized types, forming the different types of cells in our bodies. Full definition
This video shows automated computational cell lineage reconstruction of the image data.
sciencedaily.com
This could ultimately help us to understand which mutations in a patient cause permanent damage to cell lineage trees.
The team's model, still in its early stages, is hoped to form a foundation for continuing studies on germ cell lineage.
Their method can be used to trace cell lineages in multiple organisms and efficiently processes data from multiple kinds of fluorescent microscopes.
This latest study reports the generation of multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.
Upon microcarrier dissolution and cell release, the cells maintained functionality by exhibiting the correct phenotype, normal karyotype, and ability to differentiate into multiple cell lineages.
Then, they transplanted these cells into recipient mice and confirmed that the cells can form all of the blood cell lineages in vivo.
The eye is composed of highly specialized tissues that are derived from a variety of cell lineages during development.
Furthermore, despite growing circumstantial evidence that pericytes might be the in vivo native counterparts of the ex vivo MSCs, there has been no direct evidence (by prospective cell lineage tracking experiments) that pericytes display key features of stem cells including proliferation and differentiation into mature cell phenotypes in vivo following injury.
EB differentiation is a common platform to generate specific cell lineages from PSCs.
These presentations will be complemented by talks on experimentally induced cell fate changes during reprogramming to pluripotency and transdifferentiation into various cell lineages.
Can we design immunogens to stimulate specific B cell lineages, effectively launching «specific» affinity maturation pathways that lead to broadly neutralizing anti-viral responses?
These results suggest that by using the correct combination of gene products, it may be possible to reprogram more readily available pluripotent cell types to a multipotent retinal cell lineage useful in healing damaged or diseased retinas.
Lead author found guilty of misconduct in embryonic cell lineage paper called into question over a year ago
Although, remarkable progress has been made in the in vitro development of T cells from ES cells [6], [7], this has not been the case for other hematopoietic cell lineages.
Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility.
The two postembryonic touch receptor neurons in the nematode Caenorhabditis elegans arise from essentially identical cell lineages and have the same ultrastructural features.
In this case, the two ICMs were not equal and high - resolution RNA sequencing indicated that they were at different stages of development; the smaller one was in the earliest stages of cell lineage commitment, while the bigger one had already differentiated to some extent.
The research team found that two distinct B - cell lineage antibodies teamed up to stimulate the highly sought - after broadly neutralizing antibodies to HIV.
This line provided the basis for altering the expression of Pax6 in the cortical stem cell lineage such that it would be sustained in basal progenitors.
He and his colleagues, including Janelia postdoc Fernando Amat, Janelia group leader Kristin Branson and former Janelia lab head Eugene Myers, who is now at the Max Plank Institute of Molecular Cell Biology and Genetics, have used the methodto reconstruct cell lineage during development of the early nervous system in a fruit fly.
They show that these lncRNAs are often located near transcription factors in the genome of lung cell lineages.
Typically the process of tracking cell lineage over time requires biologists to watch the time - lapse images and note by hand when the cells multiply - creating a graphic representation of cell division over time called a «lineage tree.»
The accumulation of only adult stem cell - like cells indicates a mutation in the master differentiation factor bam completely blocks germline stem cell lineage differentiation.
They also ran a standard test that measures the cells» ability to produce the three major cell lineages in the body and found no differences.
«New clues to treat Alagille Syndrome from zebrafish: How Jagged genes establish liver duct cell lineage.»
The International Human Epigenome Consortium presents a series of studies on how epigenetics influences immunity, cell lineage determination, and differentiation.
Activation of the receptor leads to dendritic cell lineage specification and regulation of lipid antigen presentation.
Given our model results, we speculate a relationship between adhesion and the variance of cell lineage cluster size, which could determine the ability of microbes to cope with variability in nutrient patchiness [62 — 65].
By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.
Using spatial correlation functions to quantify the differences between emergent cell lineage segregation patterns, we find that strong adhesion often, but not always, maximizes the size of clonal cell clusters on flat surfaces.
In this regard, comprehensive cell lineage tracking experiments will significantly promote our current knowledge regarding the in vivo origin and function of MSCs.
Altogether, these findings highlight the central role of Lkb1 during neural crest cell lineage and uncovered a link between Lkb1 - mediated pyruvate - alanine cycling and glial commitment.
Dorian Freudenreich (Brand, TUD)-- «Genetic cell lineage tracing and transcriptome analysis of neuronal progenitor cells during neurogenesis and regeneration of the adult zebrafish telencephalon» (2010)
Herpesvirus entry mediator on radiation - resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry - independent manner.
ES and iPS cells are ideal for their study because these cells can be programmed into differentiating as specific somatic cell lineages that can replicate embryogenic patterns and positions.
Differentiation into distinct cell lineages is currently understood as a gradual loss of developmental potential.
Transgenic mice overexpressing arginase 1 in monocytic cell lineage are affected by lympho - myeloproliferative disorders and disseminated intravascular coagulation.
The most compelling argument for an inflammatory role has come from studies of transgenic mice that over express LIGHT in the T cell lineage.
We established several cell lineages from three independent transfection experiments and chose three lines (iPSC1, iPSC2, iPSC3) for further characterization.