Sentences with phrase «drug targets»

If additional work supports the finding, the study may provide researchers with potential new drug targets for the disease.

This research has already opened up new potential drug targets for the control or treatment of these conditions.

We are applying it to evaluate large number of potential drug targets in a faster and more systematic way than before and to select the best ones to work on.

It can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Such methods have already been applied to identify drug targets in ten genomes that cause tropical diseases.

The researchers say there is an urgent need for new drug targets in major depressive disorder.

A better understanding of gut bacteria's role in multiple sclerosis may identify novel drug targets and pathways to improved health.

His lab is now further investigating how this happens in hopes of identifying possible cancer drug targets for tumors that arise in obesity.

The results can help cancer biologists set up experiments to see how important these DNA changes really are in pancreatic cancer and whether or not they are good drug targets for potential treatments.

This can be done by diet, genetics or drugs, which is why we want to identify promising drug targets.

This makes the serotonin receptor an important drug target.

Two of these proteins are already being studied as potential drug targets against other pathogens.

Furthermore, these disease models are used for drug target identification.

So far, all have failed, leading some frustrated researchers to say it's time to move on to other drug targets.

This helps ensure selective drug targeting only at the site of the tumor.

Although antibody treatment is helpful, she sees a clear need for new drugs — and this type of data will help to prioritize the candidate drug targets.

It is triggered by the immune system, and new insights into immune processes have thrown up a number of exciting drug targets.

In an attempt to discover more effective drug targets for influenza, scientists have recently identified several genes and molecules that are crucial for influenza virus replication.

This is a welcome surprise, because it suggests a well - understood brain process might be a useful drug target for future HD research.

The company decided to set up the institute, he adds, because it expects to get «a large competitive advantage» if it can efficiently translate genetic information into drug targets.

They identified a number of characteristics that were common among successful drug targets — and especially common among high - revenue drugs.

The study findings have already led to a collaboration with a pharmaceutical company to test drugs targeting that pathway, he said.

There remain, then, thousands of potential genes (i.e. gene protein products) to develop as future drug targets.

A clinical benefit or improved patient outcome of three to eight months was seen in seven of the 19 patients (37 percent) who received drugs targeting this pathway.

Drug companies find themselves unable to reproduce promising drug targets published by the best academic institutions.

Users can enter the name of a single gene or lists of many genes to retrieve drugs targeting those genes.

In two advanced lung cancer trials, which we covered, new drugs targeting familiar faulty molecules showed promise.

It involves finding an accessible drug target and a molecule that binds that target as selectively as possible.

And the genetics is clearly pointing us toward valuable novel drug targets.

«By investigating how fungi cause disease, we have identified a new drug target with the view to design new therapies to combat these serious infections,» she said.

When developing a new drug, researchers identify drug targets based on what they know about the biology of the disease, and then create compounds that affect those targets.

The search provides the names of drugs targeted to each gene and details whether the drug is an inhibitor, antibody, vaccine or another type.

Additional genes included in the database could be the focus of future drug development efforts because they belong to classes of genes that are thought to make promising drug targets.

This makes it an exciting drug target, but until now, it has been difficult to test the effectiveness of potential new drugs on blocking the protein.

Because of that sole source for survival, the genes needed for acquisition of this nutrient could be effective drug targets.

Published online in Cell Stem Cell, the study identifies a molecular pathway that could serve as a new drug target for colon cancer treatment.

«Nobody's ever looked at nutrient transporters as drug targets because it's assumed that there will be hundreds more transporters, so it's a pointless pursuit,» Ahmer said.

Moreover, the binding with the MMP active site is discussed in the research paper, «Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors», published in Current Drug Targets.

Nuclear receptors make good drug targets because one region is bound to DNA, while a pocket sits open on another part of the protein, just waiting to hold a signaling molecule.

Doing so enabled them to identify the liver - specific drug targets whose inhibition will not cause any side effect to other human tissues, says lead author Adil Mardinoglu, a SciLifeLab fellow, who had earlier established a connection between NAFLD and HCC and increased fat synthesis in liver tissue.

Prof. Pfeifer's team has discovered multiple signaling cascades and possible drug targets in rodents that are responsible for the conversion from white - energy - storing to brown - energy - consuming fat cells.

The new approach to finding drug targets relies on looking at the whole network of interacting proteins, rather than concentrating on just those that are mutated to trigger cancers.

Therefore, this complex is a highly promising therapeutic drug target against diabetes, obesity, Wolff - Parkinson - White Syndrome, cancer, and aging.

TTP Labtech's ameon ® lifetime reader incorporates fluorescence lifetime technology, enabling cost - effective screening of common drug targets as well as challenging epigenetic targets.

When you look at this research and the past research in the field, it seems pretty clear that there's unlikely to be a one size fits all drug, but instead different drugs targeting different senescent cell profiles.

Thus, nearly half of the first neighbours of differentially expressed proteins are already been known or suspected to be associated with colon cancer, while the other half (44 proteins) could be considered as novel genes potentially relevant for anticancer drug target discovery.