Sentences with phrase «small molecule drugs»

His primary interests are novel small molecule drugs, next generation vaccines, and cell therapies.

However, while small molecule drugs can cause unwanted side effects because they are easily absorbed in the body, protein drugs can have the opposite problem: they can be too big.

These methods are useful in studying protein - protein interactions and identify and optimize small molecule drugs to inhibit these interactions.

It focuses on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

The initiative will also allow the CMI to foster new partnerships between academia and industry, and utilize the individual strengths that each possess to expedite the early stages of small molecule drug discovery.

The consolidation of these efforts in an independent initiative will allow faculty from the CMI to lead a focused investigation in small molecule drug discovery for multiple therapeutic applications.

Developing small molecule drugs for Type II diabetes and Osteoarthritis / inflammation based diseases.

By getting inside the cell and getting the body to produce intracellular proteins, we have the potential to address many diseases that today aren't druggable with small molecule drugs or biologics.

It uses its proprietary technology to create novel small molecule drug conjugates, or SMDCs, and companion imaging diagnose.

«They also provide a promising strategy for identifying small molecule drugs designed to treat Alzheimer's disease and other neurological disorders.»

«We could apply the strategy used in this study to quickly identify and design small molecule drugs for other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.

«A long - standing dream of cancer biology is to find small molecule drug compounds to restore the activity of p53,» Amaro says.

PROFESSIONAL SUMMARY * A proven leader with a track record of accomplishments with more than fifteen years pharmaceutical industry experience in leading analytical development activities for small molecule drug development * Hands - on experience in analytical project management in drug development and regulatory submissions hands - on experience in analytical method development / validation / transfer in GMP environments expertis...

Given the limited success of neurotrophic factors in clinical trials, there is a need to identify new small molecule drugs and drug targets to develop novel therapeutic strategies to protect all neurons that degenerate in PD.

Vertex Pharmaceuticals, Inc. engages in the business of discovering, developing, manufacturing, and commercializing small molecule drugs for patients with serious diseases in specialty markets.

Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and other small molecule drug cadherin - 11 inhibitors.

TLC's first project, which is also a pilot project of the TRND program, focuses on repurposing an existing small molecule drug, auranofin, initially approved to treat rheumatoid arthritis in the mid-1980s.

SGI - 110 is a novel next generation small molecule drug which inhibits DNA methylation — one of several epigenetic mechanisms that cells use to control gene expression, the process by which genetic instructions are used to synthesize gene products.

b) Drug discovery by combining screening and selection methods: Nature develops specific binding molecules (e.g. antibody) using selection, while human discovers small molecule drugs using screening.

If these aren't effective, a new class of small molecule drugs called Janus kinase (JAK) inhibitors may be prescribed.

Discovering novel small molecule drug leads depends on the ability to efficiently search chemical diversity.

As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to increase muscle function and contractility.

SOUTH SAN FRANCISCO, Calif. — February 5, 2018 — FLX Bio, Inc., a biopharmaceutical company focused on the discovery and development of oral small molecule drugs to activate the immune system against cancer, today announced the appointment of senior pharmaceutical research and development executive Michael F. Giordano, M.D., to its Board of Directors.

3BP, part of a class of compounds known as small molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.

The pathway is the same in humans as it is in flies and, because the Ras protein plays a key role in cancer, many small molecule drugs already exist, some of which have been approved for clinical use.

Hopefully, this knowledge, coupled to utility of the mAGES system, will spark the search for small molecule drug combinations which can safely and efficiently modulate the involved pathways and promote astrocyte to NSC conversion.

«We took every FDA approved small molecule drug and analyzed HLA - DQ8 binding through a supercomputer.

The cells generated in the Zeng lab may not only provide a potential unlimited source for cell replacement therapy for Parkinson's disease, but also offer an unprecedented opportunity to develop screening models for assessing small molecule drugs and to clarify the mechanisms of disease.

«We have provided evidence, in collaboration with Erich Wanker from Berlin, that such activation can be achieved, in principle, with an experimental small molecule drug [called] geldanamycin.

Alternatively, once the down stream targets of Rett's silencing effect have been determined, phamra companies have several tools in their arsenal to treat the disease, from small molecule drugs to RNAi.

Dr. Ding's work revolves around chemical reprogramming — the use of small molecule drug mixtures to coax fibroblasts into becoming a variety of other cell types.

In its inaugural collaboration that focuses on small molecule drug discovery, IACS has signed an exclusive agreement with TESARO, Inc., an oncology - focused biopharmaceutical company.

He served as Laboratory Director at biotech company, Prosetta Corporation, leading several small molecule drug discovery programs focused on viruses of interest to the United States Department of Defense.

About PTC Therapeutics PTC is a biopharmaceutical company focused on the discovery and development of orally administered, proprietary small molecule drugs that target post-transcriptional control processes.

The company provides small molecule drugs, peptides and other potential biologic drug candidates.

The company uses its proprietary technology to create novel small molecule drug conjugates and companion imaging diagnostics for personalized targeted therapies.

Dr. Bot's background is in theoretical and experimental immunology, cancer research, and biomolecule and small molecule drug development, spanning preclinical and clinical stages.

In addition, new small molecule drugs are being used that target important survival pathways in NHL tumor cells.

Vertex Pharmaceuticals is engaged in the business of discovering, developing and commercializing small molecule drugs for the treatment of serious diseases.

«Our hope is that we can develop small molecule drugs that will activate p53 in those tumors where it is still functional but inactivated by one of its negative regulators.»

The project, which emerged from work supported by Cure Network Dolby Acceleration Partners, aims to discover and develop novel small molecule drugs that reduce overall levels of tau in the brain to prevent and slow the progression of Alzheimer's disease and related conditions.

«We are very excited about the prospect of using these more physiologically relevant cell - based models for gene and small molecule drug discoveries,» says Dr. Andrew Liu, Assistant Professor of Biology at the University of Memphis.

ACADIA Pharmaceuticals Inc. is focused on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

This would be a logical worry if Humira was a small molecule drug.

But, says Michael Varney, head of the small molecule drug discovery group at Genentech, those hiring trends are about to change: «For us, over the next 3 years, we'll hire more medicinal chemists and more process and scale - up chemists than we will analytical chemists.»

The study published today in Cell and funded by the Max Planck Society and Wellcome Trust shows for the first time that a small molecule drug, which limits the effects of a protein called Ras, can delay the aging process in animals.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.