Sentences with word «phosphorylation»
Phosphorylation refers to a process where a molecule called phosphate is added to another molecule. This addition of phosphate helps regulate and activate various processes in cells, such as controlling the activity of proteins and turning on or off certain cellular functions. Full definition
We also show that inhibition of the PI3K / AKT pathway in ALK + ALCL cell lines decreased the level of phosphorylation of mTOR and mTOR signaling proteins.
cancerres.aacrjournals.org
In the early 1950s, he shifted his focus to biological phenomena and studied the control of oxidative phosphorylation in mitochondria and revealed the role of ADP in respiratory control.
Justin Drake, a postdoctoral researcher in Witte's lab at UCLA (now an assistant professor at Rutgers Cancer Institute of New Jersey), led the phosphoproteomics work, producing a new encyclopedia of protein phosphorylation in prostate cancer cells and tissues.
Zhang, Y. and Wolf - Yadlin, A. and Ross, P. L. and Pappin, D. J. and Rush, J. and Lauffenburger, D. A. and White, F. M. (2005) Time - resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
The idea that both STAT2 and IRF - 9 were basic components necessary for RIG - G expression was also supported by the fact that ATRA could not only induce the total amounts of STAT2 and IRF - 9 proteins but also increase the tyrosine phosphorylation level of STAT2 in NB4 cells (Fig. 1A).
For example, our past work showed that two conserved tyrosine phosphorylation sites in the juxtamembrane segment of the Eph receptors not only mediate association with binding partners but also regulate receptor kinase activity.
GS is covalently modified by phosphorylation at nine serine residues by several protein kinases.
His discovery of protein phosphorylation as a regulatory mechanism (with Edmond Fischer) touched all aspects of biomedical science and profoundly influenced therapeutic approaches now widely used in clinical care.
ActD caused AKT phosphorylation at Ser473, indicating full activation of AKT.
Antibiotic Resistance, Houston, TX, USA presentation «Adaptive Mutations in LiaR are Sufficient to Confer Daptomycin Resistance in E. faecium by Inducing Phosphorylation - Independent Activation of the LiaFSR - mediated Membra...
Changing a signaling molecule's phosphorylation status elicits specific changes in the molecule's activation status.
Panel F. Akt phosphorylation at pS473 was also measured by ELISA in enhanced hiPS - HEP cells from C18 on Day 6 post-thawing (n = 1 for each treatment concentration).
Yang and co-author Chunru Lin, Ph.D., an assistant professor in the same department, confirmed four sites for phosphorylation, a process that turns protein enzymes off and on, impacting key cellular functions.
The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Amyloid - beta oligomers through Tau phosphorylation on S262.
We also show that inhibition of mTOR with rapamycin, as well as silencing mTOR gene product expression using mTOR - specific small interfering RNA, decreased phosphorylation of mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells.
In 1996, Peter Klein of the University of Pennsylvania discovered that one of lithium's biological activities was inhibiting GSK - 3, an enzyme that modifies other proteins by attaching phosphate molecules, a process called phosphorylation.
AKT activation contributes to mTOR phosphorylation in ALCL cells.
The next slide, a little bit more about Fox01; Fox - 01, as I mentioned, is activated by Akt through phosphorylation.
Given that modifications such as phosphorylation are likely to be impermanent and reversible, the clinical implications are far - ranging.
Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53 - MDM2 functional circuit response in the IUGR rat kidney.
Finally, we will carry out a small phosphoproteomics study to identify host proteins whose phosphorylation state changes during T. gondii invasion.
Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.
We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.
In conclusion, the proteomic approach revealed that cellular stretching induced specific phosphorylation changes in chondrosarcoma cells.
Codonopsis (Radix Codonopsis Pilosulae) Codonopsis extract has been shown to support liver health by modulating phosphorylation of AMPKalpha and ACC, which are implicated in lipid metabolism.
Trametinib inhibits RAS - mutant MLL - rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo
However, it is unclear whether this enhanced interaction selectively facilitates transcription of specific p53 target genes, including sestrins, or whether p53 serine18 phosphorylation also regulates specific target genes by altering interactions of p53 with other coactivators such as chromatin modifying enzymes.
Mutations that affect phosphorylation of the adenovirus DNA - binding protein alter its ability to enhance its own synthesis
This causes reduced phosphorylation of 4E - BP1 and p70S6K1, thereby inhibiting protein translation.
Tyrosine is an amino acid present in proteins that contains a hydroxyl moiety, and kinases are enzymes that catalyze phosphorylation (addition of a phosphate group) of various substrates in the cell.
Specifically, they looked at eIF2alpha phosphorylation and the regulation of protein synthesis in the mice's hippocampus region — the part of the brain responsible for the retrieval of old memories and the encoding of new ones.
Increased p70s6k phosphorylation during intake of a protein - carbohydrate drink following resistance exercise in the fasted state.
Right panel: several colon cancer cells were investigated for constitutive activation of RIPK2 using phosphorylation specific antibodies to pY474 and pS176 as indicated.
Searching for those substrates and trying to unravel how phosphorylation affects their activity has kept Hunter and his lab busy for more than three decades.
Salicylanilides are very lipophilic and may shuttle protons across membranes, particularly the inner mitochondrial membrane, thus removing the proton gradient and uncouple oxidative phosphorylation [6, 7, 15].
Blueberry - induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain - derived neurotrophic factor (BDNF) levels.
The model was constructed to predict the receptor phosphorylation levels in a cell under specific conditions for the immediate - to - short (minute - to - hours) response durations.
Our preliminary data have shown that p53 directly interacts with a component (MED17) of the multi-subunit Mediator coactivator complex, which is an essential part of the general transcription machinery, and that serine18 phosphorylation enhances this interaction.
In addition, the Benz lab will explore new therapeutics (kinase inhibitors) capable of altering the ER phosphorylation pattern to restore treatment sensitivity to resistant ER breast cancers.
«Now, we need to better understand how this works at the molecular level so we can perhaps design therapeutics to prevent phosphorylation of that site.»