Sentences with phrase «gene in mice»

Researchers have just completed a library of all the active genes in the mouse genome.

By knocking out individual genes in the mouse, they can systematically discover any that have a crucial biological role, or are linked with disease.

To study these pathways, we use a range of in vitro and in vivo approaches, including manipulating genes in mice and leveraging genome - wide analyses and chemical biology.

Also, knocking out the leptin gene in mice showed that this hormone regulated appetite.

The challenge then is to replace the intact, functional gene in the mouse chromosome with the modified version created in the test tube.

This image illustrates concepts in the press release titled «Infradian oscillation of circadian genes in a mouse model of bipolar disorder».

Giulio Superti - Furga congratulates Denise Barlow who recently went into retirement to her great scientific achievements and for revealing the full picture of imprinted genes in the mouse.

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

In 2016, the research team spotted mice that sleep for extraordinarily long periods and ones that have extraordinarily short REM sleep in a sample of about 8,000 specimens, and discovered mutations of particular genes in those mice with unique sleep patterns.

In a mouse model of eczema, loss of the HTR7 gene in mice led to significantly less scratching and less severe skin lesions.

For a decade, the group at North Carolina has studied a large family of genes in mice called L1, some of which are dormant.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

The researchers therefore decided to take a closer look at the protein - encoding genes in the mouse tumors.

After four weeks of such training, researchers reactivated the p25 gene in the mice for six weeks and then tested them to see if they recalled their shocking experiences.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

Researchers found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

A large - scale study, published in Wellcome Open Research and which passed peer review today, has shown that inactivating the same gene in mouse embryos...

«Infradian oscillation of circadian genes in a mouse model of bipolar disorder.»

By manipulating a specific gene in a mouse blastocyst — the structure that develops from a fertilized egg but is not yet an actual embryo — scientists with the University of Florida's McKnight Brain Institute and the Harvard Stem Cell Institute caused cells destined to build an embryo to instead change direction and build the cell mass that leads to the placenta.

mm10 loss developmental genes are genes in mouse loss hotspots that are annotated with developmental process GO terms.

Olson study identifies gene in mice that may be linked to emotional learning, fear response, risk seeking in humans

In parallel, we will investigate the accumulation and function of transcription coactivators, including the Mediator and different histone modifying enzymes, on endogenous sestrin genes in mouse cells expressing wild type versus serine18 mutant p53.

Using the gene - editing tool CRISPR - Cas9 to turn off certain genes in a mouse zygote as well as other new techniques to enrich the pluripotent stem cells of a rat, the group managed to grow various rat organs (a pancreas, heart, and eyes) in a mouse embryo.

Previously it was reported that around 3 % of X-chromosomal genes in mice and 15 % in humans escape inactivation.

These experiments revealed that the CLOCK protein targets the per gene in mice and both the per and tim genes in flies.

Research on SLC13A5 has focused on its role in obesity and diabetes; knocking out the SLC13A5 gene in mice prevents high - fat diet - induced obesity.

Like Jirtle and Waterland in 2003, Whitelaw focused on the agouti gene in mice, but the implications of her experiment span the animal kingdoms.

Initial testing of mTOR inhibition was achieved by direct deletion of the mTOR gene in mice.

The researchers used the dead guide RNAs to turn on the Pdx gene in the mice's livers, which caused the liver cells to produce insulin, reversing the mice's diabetes.

PUMP IT UP A new type of CRISPR / Cas9 - based gene therapy turned on muscle - building genes in mice that have muscular dystrophy.

In it, he reported conclusive proof that there is a human equivalent of the so - called fat gene in mice.

The second study, led by Gwenaëlle Géléoc, PhD, of the Department of Otolaryngology and F.M. Kirby Neurobiology Center at Boston Children's, used Anc80 to deliver a specific corrected gene in a mouse model of Usher syndrome, the most common genetic form of deaf - blindness that also impairs balance function.

«But there are 50 - plus MHC genes in mice, and we don't know what most of them do.

To find answers to these questions, the scientists studied the gene regulation of the DPP4 gene in mice that are prone to obesity.

Functional deletion of the β - arrestin 2 gene in mice resulted in remarkable potentiation and prolongation of the analgesic effect of morphine, suggesting that μOR desensitization was impaired.

Balkwill's lab turned off the TNF gene in mice so that the rodents could not produce the protein: to the researchers» surprise, the mice did not contract tumors.

When Robertson knocked out the Igf2 gene in mouse mothers, nothing happened; the offspring were normal.

Deletion of the GM - CSF gene in the mouse led to reduction and impaired regulatory function of gut tissue macrophages and dendritic cells which compromised induction of tolerance to food antigens and increased mice susceptibility to IBD.

«We anticipate a similar mode of action may operate in other organisms because similar RNAs have been found for clock genes in mice.

In contrast, the researchers found that many of the DNA regions controlling cytokine genes in the mice's T cells are inaccessible and silenced prior to exposure to a pathogen.

For their experiments, the researchers mutated one of the two copies of the KRAS gene in mice.

Moving their studies from cells to whole animals, the researchers tested the effects of knocking out the Zbp1 gene in mice infected with influenza.

Eliminating genes in mice is a standard technique for determining their function; the resultant animals are called knockout mice.

Researchers commonly delete and disable genes in mice, fruit flies, yeast and other laboratory critters to investigate the genes» normal roles, but have never done this before in human embryos.

In addition, loss of the Esrp1 gene in mice leads to changes in the shape of the inner ear that is very similar to the situation with the siblings.