Sentences with phrase «cell fate»

Particularly, he is interested in the analysis of stem cell fate decisions and of individual stem cell clone dynamics.

The concentration of each regulator would ultimately influence this network and neural stem cell fate with the options of self - renewal, differentiation or tumor development.

We are interested in the molecular mechanisms that regulate cell fate.

Previously, making these cell types took weeks to months, primarily because it wasn't possible to accurately control cell fate.

The study sought to test whether the surface alone, absent any added soluble factors to influence cell fate decisions, can have an effect on differentiation.

The pathway that it takes decides in which valley it will finally settle, providing a metaphor for the acquisition of a specific cell fate.

In collaboration with experimental groups we use methods from statistical physics to study mechanisms of cell fate regulation in tissue development, maintenance and disease.

Another view is that tumors can become resistant to therapy by a process called cell fate decision, by which some tumor cells are killed by therapy and others become cancer stem cells.

The relative simplicity of the process means biologists have a much greater chance of reliably influencing stem cell fate.

The question of cell fate regulation can be asked on different scales.

We are also investigating endocytosis of the cell surface receptor, Notch, a protein involved in cell fate specification (6).

Chen's team found that rounded cells had less active Rho than stretched cells, suggesting that cell shape determines cell fate by turning Rho on or off.

With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?

In the large Drosophila melanogaster oocyte, asymmetrically localised cell fate determinants specify the body axes and pattern the future embryo and fly, making it an ideal model for the study of RNA localisation.

Our current works have focused on screening the chemical libraries to identify and further characterize small molecules that can control stem cell fate in various systems.

These presentations will be complemented by talks on experimentally induced cell fate changes during reprogramming to pluripotency and transdifferentiation into various cell lineages.

Drosophila Condensin II subunit Chromosome - associated protein D3 regulates cell fate determination through non-cell-autonomous signaling.

From tens of ES cells, nature normally guide the differentiation into hundreds of different cell fates during embryonic and fetal development through various signals, including proteins (cytokines).

Among them, there are genetic instability (mainly aneuploidy, a defect in chromosome number), defects in the symmetry of cell division (important for cell fate specification and tissue architecture) and impaired ciliogenesis.

He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.

Abstract During muscle regeneration, the conversion of muscle stem cells to terminally differentiated myofibers requires multiple cell fate transitions.

[5] D. Sarkar et al., «Cellular and extracellular programming of cell fate through engineered intracrine -, paracrine -, and endocrine - like mechanisms,» Biomaterials, 32:3053 − 61, 2011.

Gradients of BMP signaling in zebrafish embryos direct dorsal - ventral cell fate specification during embryogenesis.

Mutations may bias progenitor cell fate towards proliferation.

Cells are only transiently pluripotent as cell fate specification signals initiate differentiation soon after the formation of pluripotent blastomeres.

In the paper, JAX Professor Martin Pera, Ph.D., and Assistant Professor Christopher Baker, Ph.D., note that more refined knowledge of the differences between pluripotent and totipotent stem cells is needed, particularly the molecular regulatory networks that govern cell fate decisions in early mammalian development.

Here, we review work that has revealed the central role that physical forces and extracellular matrix mechanics play in the control of cell fate switching, pattern formation, and tissue development in the embryo and how these same mechanical signals contribute to tissue homeostasis and developmental control throughout adult life.

These experimental systems allow scientists to dissect key molecular pathways that specify cell fate decisions in embryonic development,» said team leader Lin He, a UC Berkeley associate professor of molecular and cell biology.

Specifically, we investigate the molecular events regulating developmental decisions that instruct cardiac progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart.

GLS - 1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions.

She is testing the long - held tenet that Wingless function requires spread from its site of synthesis to form a gradient that specifies distinct cell fates as a function of ligand concentration.

Research Interests: Molecular control of cell fate from stemness to differentiated skeletal and neuronal cell types; SOX transcription factors; skeletal malformation and degeneration diseases; intellectual disability and autism spectrum disorders; mouse genetic models; human pluripotent stem cell differentiation models in vitro

His work has focused on discovering and characterizing novel small molecules that can control various cell fates and functions, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues.

A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha.

In contrast to the conversion of alpha cells, which only concerns a small fraction of the alpha cell population, the new mechanism involving delta cell fate change is a more efficient way of offsetting the loss of beta cells and thus diabetes recovery.

They discovered novel mechanisms in cells with the ability to activate pathways that crosstalk one to another and then assemble consolidated responses that decide cell fate.

«In addition to advancing our understanding of human embryonic development, the findings suggest we may be able to use metabolites, relatively simple compounds, to alter cell fate in the treatment of common disorders.»

Cas is required for polar and stalk cell fate specification, while Eya is a negative regulator of these cells» fate.

In this webinar, Dr. Stoddart will show identifying cell fate of mesenchymal stem cells is more accurate and specific when studying the expression ratios of multiple targets as opposed to studying them in isolation.

The target of the new drug is an enzyme in cancer stem cells and tumor cells called Polo - like kinase 4, which was selected because blocking it negatively affects cell fate decisions associated with cancer stem cell renewal and tumor cell growth, thus stopping tumor growth.

«What changes a cell, or what regulates a cell to follow certain cell fate decisions?