Sentences with phrase «therapeutic targeting»

«This makes it important to identify new therapeutic targets for the development of effective treatments,» the investigators conclude.

In addition, these findings may expand the number of possible new therapeutic targets for this disease.

This has prevented the identification of potential therapeutic targets for clinical intervention.

His current research focuses on the identification and validation of therapeutic targets in pediatric solid tumors and rare cancers.

The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.

The new enzymes could serve as therapeutic targets for drug developers.

Certain compounds that are involved in oxidative stress look like promising therapeutic targets.

In turn, that means researchers may be able to pinpoint circuits that cause the disorder and map possible therapeutic targets.

However, the next 5 years will see great improvements in our understanding of the biology which will lead to better therapeutic targets.

To do that, large compounds libraries are tested on a biological model showing a specific therapeutic target.

Furthermore, results may encourage other research groups to use the M2 channel of influenza virus as therapeutic target against the influenza A virus.

These mutations could become therapeutic targets because there are already drugs blocking the activity of these genes which may be useful in complicated cases of mantle cell lymphoma.

These findings further suggest that enhancing self - compassion can potentially be an important therapeutic target.

Their involvement has been demonstrated in several diseases, among which chronic inflammation and cancer; therefore, they have been considered interesting therapeutic targets.

The other contribution of this study was the identification of potential alternative therapeutic targets.

For a stronger recommendation of iron depletion as a valid therapeutic target in heart failure, well - designed and controlled studies with adequate follow - up are needed.

This can help identify new molecules likely to inhibit certain therapeutic targets and to lead to novel drug candidates.

They may also be prime therapeutic targets to treat a range of diseases.

Potential therapeutic target molecules in these pathways will be highlighted in the conference.

For the later stages of my career, I have been thinking about therapeutic targets and the development of new drugs.

The goal of this work is to develop novel therapeutic targets based on increased understanding of the interaction of tumor cells and immune cells.

The authors conclude that these genes may represent new therapeutic targets for HD.

Several novel therapeutic targets have already been identified, and drug discovery efforts continue.

However, a great deal of basic research is still required to understand the molecular bases of rare diseases and identify potential therapeutic targets.

Previous research suggests it could be a promising therapeutic target.

The ultimate goal of this work is to identify therapeutic targets in both the heart and spinal cord....

This technology helps researchers connect mutations in the so - called genomic «dark matter» with the genes they affect, potentially revealing new therapeutic targets for genetic disorders.

Therefore, correction of iron deficiency itself should be considered an attractive therapeutic target in this population.»

Summary: Chicago researchers have discovered that a chaperone protein from yeast can regulate the folding not only of yeast but also mammalian prions, providing therapeutic targets for diseases like «mad cow» or CJD.

«Our findings have important translational value since they establish this protein enzyme as a novel and viable therapeutic target with real disease - modifying potential for AD,» Praticò said.

Our results therefore suggest that arterial stiffness represents a major therapeutic target by which an otherwise intact physiological machinery may be exploited for blood pressure regulation.

Carmot's vision is to become a leader in drug discovery by generating superior drugs for challenging therapeutic targets.

Our program constitutes a highly interdisciplinary group addressing these important questions, which results in the identification of new and more selective therapeutic targets not only for cancer but also for other pathologies.

Moreover, this pathway, specifically GARP, may be a potential future therapeutic target for treatment.

«Neuroscientists are using these new gene - editing and molecular tools to develop potential therapeutic targets across multiple disease fronts.»

«Since neurotrophins and their receptors control the communication between the brain and peripheral organs, they could be new therapeutic targets with implications in both metabolic and neurologic diseases.»

Besides intracellular signal transduction, a host of other therapeutic targets were discussed for the mediation of the anticancer activity of anthelminthics, ranging from inhibition of mitochondrial respiration, glucose utilization, cellular stress response and others.

«To our knowledge,» the authors wrote, «our study is the first to explore cfDNA systematically as a means to identify therapeutic targets not detectable from standard tissue - based testing in untreated metastatic disease.»

This novel model also has the potential to help find new therapeutic targets within the immune system and to help design vaccines for patients who do not typically respond to immunotherapy.

Ongoing epidemiological and genomic surveillance is imperative to identify viral determinants of transmission dynamics, monitor viral changes and adaptation, ensure accurate diagnosis, guide research on therapeutic targets, and refine public health strategies.

Scientists Show Prions Mutate and Adapt to Host Environment — The findings from the Weissmann lab point to normal prion protein as the most effective therapeutic target for «mad cow» and related diseases.

«The more steps in the mechanism we can understand, the more therapeutic targets we'll find for Alzheimer's disease.»

Members of the steroid receptor coactivator (SRC) family of oncogenes are especially promising as therapeutic targets because these proteins sit at the nexus of key signaling pathways that cancer cells use to quickly grow, spread to other tissues, and acquire drug resistance.

Determining the individual contributions of each protein will help provide strategic therapeutic targets to change the course of a patient's psoriasis or, at the very least, provide a better understanding of how a change in the regulation of these proteins contributes to skin inflammation and psoriatic disease.

Dario C. Altieri, M.D., Wistar's President and CEO and lead author of the study, and colleagues showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas — a type of brain tumor — and how the pathway could be a valuable therapeutic target in cancer.

Extracellular interactions are excellent therapeutic targets because they are directly accessible to systematically delivered drugs such as monoclonal antibodies.

Functional Kinomics identifies candidate therapeutic targets for head and neck cancer.