Sentences with phrase «cell cycle»
The phrase "cell cycle" refers to the series of events that a cell goes through as it grows and divides into two daughter cells. Full definition
His research interests are mechanisms of cell cycle control and initiation of DNA replication using biochemical and microscopy techniques.
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His team discovered these special sequences are distributed throughout the human genome, embedded in multiple genes as shown in the study in Cell Cycle.
These pathways are interconnected with cell cycle control and DNA damage response.
Specifically, the data reveal distinct transitions in factors that influence the different cellular states including cell cycle regulators, transcription factors, and signaling factors.
The research, published in the journal Cell Cycle, has important implications for future cancer prevention and treatment.
They found the agent not only stalled the tumor cell cycle but also caused the immune system to mount an attack on the tumors.
It plays an important role in keeping the integrity of the cell membrane and sustaining full cell cycle functionality.
The results have been published in the journal Cell Cycle.
Ralf Kittler (Buchholz, MPG)-- «Functional genomic analysis of cell cycle progression in human tissue culture cells» (2006)
After twenty years of research, the cohesin complex still manages to surprise us regularly, as new functions in new areas of cell cycle regulation come to light.
Dowdy and colleagues painstakingly counted the number of phosphates added to Rb during cell cycle progression.
Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression — the process of cell division and replication — activates a key tumor suppressor, rather than inactivating it as previously thought.
Sulforaphane induces cell cycle arrest by protecting RB - E2F - 1 complex in epithelial ovarian cancer cells.
Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).
Jana Sontheimer (Pisabarro, TUD)-- «Functional characterization of proteins involved in cell cycle by structure - based computational methods» (2012)
«Defects on cell cycle control were also obvious from gene expression on these cells.
They will follow this approach to design a novel treatment plan by rationally combining gemcitabine with cell cycle checkpoint inhibitor, oxygen - enrich gas inhalation, and radiotherapy to significantly inhibit the growth of aggressive glioma.
Such periodic behavior — a primitive version of cell cycle events — emerged in the system because the synthesized proteins could diffuse out of the compartment through the capillaries, mimicking natural protein turnover behavior in living cells.
We also show that inhibition of mTOR expression or activity markedly decreased activation of the mTOR pathway associated with cell cycle arrest and apoptosis in ALK + ALCL cells.
This approach could also be used in many different contexts, not only for cell cycle analysis,» adds Prof. Dr. Dr. Fabian Theis, head of the ICB.
Topics spanned the entire field of cancer research, from molecular studies of cell cycle proteins to the role of vegetable consumption in cancer prevention.
Currently we are using new transgenic approaches to mark and isolate the proliferating cardiomyocytes and we generate single - cell transcriptomics and regulomics data to identify the mechanisms inducing cell cycle re-entry.
Philipp Weissert (Tanaka, MPG)-- «Bmp proteins in urodele myotube cell cycle re - entry and in regeneration» (2008)
Beerman I, Seita J, Inlay MA, et al., Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.
Kareta MS, Sage J, and Wernig M, Crosstalk between stem cell and cell cycle machineries.
The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.
Moreover, the Galli group studies cell cycles that lead to polyploidization, such as endoreplication and endomitosis, and how these cycles are regulated in normal physiology and in disease.
Upon joining the lab, Lee chose a high - risk project — «it sounded like more fun,» she says — aimed at determining whether a key gene in the yeast cell cycle, cdc2, was also present in human cells.
In the first cell cycle after fertilization the maternal genome inherited from the oocyte (egg) and the paternal genome provided by sperm exist as separate nuclei in the zygote.
Soufi A and Dalton S, Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming.
They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells.
Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.
They use genetics, imaging and sequencing based approaches in C. elegans and mammalian systems to explore the establishment and function of various cell cycle programs.
No overtly altered cell cycle parameters or aberrations in centrosome number were detected in Rassf1A null fibroblasts.
Breeden, Prentice and Zhao, whose study appeared in the May 8 Proceedings of the National Academy of Sciences, compared their new algorithm to other methods used to analyze microarray experiments designed to identify cell cycle genes in yeast.
«Cdk2 cell cycle kinase seems to play a role in the ability of cancer cells to be more aggressive and resistant to standard chemotherapy,» Dr. Opyrchal said.
GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells.
45) * Coe BP, * Lockwood WW, Girard L, Chari R, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2006) Differential regulation of cell cycle pathways in small cell and non-small cell lung cancer.
Therefore, a novel therapeutic approach in inflammatory breast cancer could involve a combination of conventional chemotherapy with small - molecule inhibitors of the Cdk2 cell cycle kinase.
The researchers said the findings fundamentally change the understanding of G1 cell cycle regulation and the molecular origins of many associated cancers.
The NCR factor that Digistain measures is known to be common to a wide range of cancers, as it occurs when the reproductive cell cycle gets disrupted in the tumour and cell nuclei get distorted with rogue DNA.
In Grossman's lab, she explored how bacteria time DNA replication, ensuring that the genome is promptly copied no more than once per cell cycle.
Significantly, treatment with 6AN specifically decreased the activity of genes with malignant, cancer - spreading functions, like cell cycle control and DNA repair.