Sentences with phrase «in gene expression»

Then, she was more interested in the rapid change in gene expression patterns stimulated by environmental stress, which is anything but subtle.

The group looked for differences in gene expression by comparing levels of messenger RNA — the middle - man between gene and protein production — throughout the entire genome.

For instance, protein and DNA modifications involved in gene expression in kidneys must at some point be turned off.

Dairy's fatty acids may also play a role in gene expression and hormone regulation.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein coding genes.

They found significant differences in gene expression patterns and DNA modifications between donors under the age of 9 and those older than 28.

Hence, any variation you see in these traits must be due to shifts in gene expression, whether that shift is determined genetically or by some external cue.

He is interested in gene expression regulation, computational biology, and data visualization.

The study's 31 samples of dog tumors was compared to 40 normal canine tissues samples as a way of estimating the variance in gene expression.

We are particularly interested in how cells use gene networks to make robust decisions even in the presence of significant fluctuations in gene expression.

In short, these changes in gene expression adversely affect the plant's ability to grow and reproduce.

We find that overall males and females differ very little in gene expression, despite having altered behavioral responses to the same odors.

This spectrum in gene expression is reflected in the ability of cells to undergo self - renewal or to form specific differentiated cell types.

The aging process is accompanied by changes in gene expression.

In the healthy weight subjects, the difference in gene expressions were not significant.

Age - induced accumulation of nuclear DNA damage, decline in mitochondrial function and alterations in gene expression have been thought to contribute to aging.

«What we're seeing may not only be happening in limbs, but the action of these two families of growth factors could be very important for the genesis of a wide range of organs in the body,» said Juan Carlos Izpisúa Belmonte, a professor in the Gene Expression Laboratory at Salk and the principal author of the Cell paper.

«Our findings set the stage for the development of iPSC - based therapies for devastating genetic disorders such as sickle cell disease,» says the study's principle investigator, Juan Carlos Izpisua Belmonte, a Salk professor in the Gene Expression Laboratory.

«We observed small but significant changes in the gene expressions between normal and diabetic corneas,» said Mehrnoosh Saghizadeh Ghiam, PhD, assistant professor of biomedical sciences and neurosurgery, a researcher in the Regenerative Medicine Institute Eye Program and the lead author of the study published in the journal PLOS ONE.

It is not clear which exact biomarker or combination of biomarkers is responsible for changes in the gene expression as there is a lot happening in the intestinal soup.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

He has more recently also been studying changes in gene expression with microarrays during epileptogenesis.

Previous research has shown that HIV - 1 integrates more frequently into human genes that are transcribed into RNA (the first step in gene expression), but the biological significance of this targeting has been unclear.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type.

To measure changes in gene expression from different species, White and Gilad developed the first multi-species gene array.

When the researchers started taking weeds out of the corn at early points, such as when the corn had as few as two and four leaves, they still saw differences in gene expression when compared to corn without weeds.

Key proteins involved in gene expression depend on each other when forming a heart in an embryo, but, if left alone, they start to run amok

For example, cultured cells exhibit rhythmic oscillations in gene expression where there is no input from the master clock.

A distinctive pattern of changes in gene expression occurs in those RA patients who have a good - response to a TNF inhibitor at three months, but not in non-responders

DNA microarray was used to evaluate changes in gene expression following one hour of treatment of HT22 neuronal cells with 10 μM J147.

The research team demonstrated that ranking genes based on inter-tumor variation in gene expression outperforms traditional analytical approaches.

This is just the first of a series of similar studies, said Gilad, that will look at changes in gene expression over evolutionary time.

«Can we find similarities in the gene expression occurring in this early stage and in the cell types developed in the blastema?»

These iPS cell clones appear to be equivalent to embryonic stem cells in gene expression and are competent to generate germline chimeras.

Real - time (quantitative) PCR (qPCR) can overcome these drawbacks and has widespread and proven use in gene expression analysis at both low and medium throughput.

Dr. Moore's research at UMMS and HHMI encompassed a broad array of topics related to the role of RNA and RNA - protein (RNP) complexes in gene expression and touched on many human diseases including cancer, neurodegeneration and preeclampsia.

To better visualize changes in gene expression programs during differentiation, we performed k - means clustering analysis, followed by hierarchical clustering, to group genes by their timing of induction or suppression during the normal ES cell differentiation process.

Objective: Research microbiologist with 3 years of postgraduate research in gene expression and metabolism of E. coli would like to apply knowledge within an industry setting.