Sentences with word «hematopoietic»

Devine SM, Hoffman R. Role of mesenchymal stem cells in hematopoietic stem cell transplantation.

The discovery could provide insight for using megakaryocyte - derived factors, such as TGF - B1 and FGF1, clinically to facilitate regeneration of hematopoietic stem cells, he adds.

The team used CRISPR - Cas9 to correct the disease - causing mutation in hematopoietic stem cells — precursor cells that mature into red blood cells — isolated from whole blood of sickle cell patients.

Basso - Ricci L, Scala S, Milani R, Migliavacca M, Rovelli A, Bernardo ME, Ciceri F, Aiuti A, Biasco L. Multiparametric Whole Blood Dissection: A one - shot comprehensive picture of the human hematopoietic system.

HSV - sr39TK positron emission tomography and suicide gene elimination of human hematopoietic stem cells and their progeny in humanized mice.

The FLT3 - signaling pathway controls cell proliferation and survival, particularly of hematopoietic progenitor cells.

«Treating myasthenia gravis with autologous hematopoietic stem cell transplants.»

By using a humanized sickle cell anemia mouse model, we show that mice can be rescued after transplantation with hematopoietic progenitors obtained in vitro from autologous iPS cells.

For example, we have no information about how these newly - generated HPCs will compete with autologous bone marrow cells for hematopoietic niches in the recipient mice.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

Microarray profiling using the Affymetrix Mouse Genome 430 2.0 array, defines sets of genes that are specific to bone marrow - derived hematopoietic stem cells and their different immunological progeny.

Studies to improve the knowledge of genetic diseases include the natural history study for MLD, advanced diagnosis and natural history of primary immunodeficiencies and immunedysregulatory disorder, and immune reconstitution after hematopoietic stem cell transplantation for genetic disorders.

For more on the different stem cell types, see a variety of previous Biology Bytes articles, including ones on hematopoietic stem cells, human embryonic stem cells, mesenchymal stem cells, endometrial regenerative cells, induced pluripotent stem cells, direct reprogramming, bioengineering organs, treating HIV with stem cells, Hans Keirstead, cancer stem cells, and cancer vaccines.

It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).

Constitutive activation of tyrosine kinases by chromosomal translocation, 1 interstitial deletion, 2 internal tandem duplication, 3 and amino acid substitution4 have been observed in hematopoietic malignancies including acute myeloid leukemia (AML) and myeloproliferative disorders (MPDs).

Thursday, Oct. 20, 10:00 - 10:15 am, Ballroom C, West Building Platform Presentation: Comprehensive population - based genome sequencing provides insight into hematopoietic regulatory mechanisms M. Guo, Boston Children's Hospital, Broad Institute, et al

The chemokine receptor CXCR - 4 is expressed on CD34 + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell - derived factor - 1.

Researchers experimentally mimic the «Berlin patient» by creating an HIV - resistant selectable stem cell population which can reconstitute the mouse hematopoietic system and resist HIV infection

They acknowledge modest benefit from hematopoietic stem cell transplantation in cardiac disease and ameliorative but noncurative outcomes in autoimmune diseases.

This process (see figure) started with spin - embryoid body (spin - EB) formation from cultures of single - cell hiPSC suspensions in 96 well plates, and the subsequent addition of BMP4 and FGF - 2 to induce mesoderm differentiation, and then VEGF and SCF to induce hematopoietic differentiation.

Here we describe a method for fabricating «bone marrow — on — a — chip» that permits culture of living marrow with a functional hematopoietic niche in vitro by first engineering new bone in vivo, removing it whole and perfusing it with culture medium in a microfluidic device.

Woolthuis CM, Mariani N, Verkaik - Schakel RN, et al., Aging impairs long - term hematopoietic regeneration after autologous stem cell transplantation.

Other adult stems cells exist — such as hematopoietic stem cells, which can generate all types of blood cell and mesenchymal stem cells, which can turn into bone, fat and cartilage cells.

Stem cell gene therapy for sickle cell disease Dr. Donald Kohn, professor of pediatrics and microbiology, immunology and molecular genetics in the life sciences and colleagues successfully established the foundation for using hematopoietic (blood - producing) stem cells (HSC) from the bone marrow of patients with SCD to treat the disease.

Stowers researchers discovered that megakaryocytes directly regulate the function of murine hematopoietic stem cells — adult stem cells that form blood and immune cells and that constantly renew the body's blood supply.

Selection - free genome editing of the sickle mutation in human adult hematopoietic stem / progenitor cells.

«Hematopoietic Fingerprints» is an expression database of postnatal stem cells and their progeny.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life - threatening severe acute graft - versus - host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

Note that Advanced Cell Therapy does not include Hematopoietic Stem Cell Transplants (HSCT), unless the cells are more than minimally manipulated before they are administered.

«A large number of quiescent hematopoietic stem cells was activated simultaneously when the epigenetic control provided by genomic imprinting was removed,» explains Venkatraman.

Kim Y - S, Wielgosz M, Hargrove P, Kepes S, Gray J, Persons D, Nienhuis A. Transduction of Human Primitive Repopulating Hematopoietic Cells with Lentiviral Vectors Pseudotyped with Various Envelope Proteins.

Review of «Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. Atkinson

MSC do not express hematopoietic markers, but a specific pattern of molecules, such as SH2 (CD105), SH3, SH4 (CD73) and STRO - 1.

One postdoctoral position is available in the Human hematopoietic development and disease modeling unit, headed by Andrea Ditadi at SR - Tiget

Along the way, we became interested in using cord blood as an alternative donor source for hematopoietic reconstitution after myeloablative therapy.

Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice.

Here, ES cells transduced with HOXB4 were analyzed for the expression of hematopoietic markers after 26 days of differentiation.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

Marie - Dominique Filippi, PhD, PhD Cincinnati Children's Hospital Medical Center Cincinnati, OH Mitochondrial Morphology Controls Hematopoietic Stem Cell Self - Renewal and Confers Them Divisional Memory

The researchers focused on how hematopoietic stem cells developed into one of two types of white blood cells: macrophages or neutrophils.

Under his direction, plasmid DNA, CAR - T - cells, regulatory T - cells, engineered stem cell grafts and gene modified hematopoietic stem cell products have been manufactured and released for use in Phase I / II clinical trials.

Clonal expansion capacity defines two consecutive developmental stages of long term hematopoietic stem cells.

RhoH is a newly identified hematopoietic small G protein, originally cloned as one of the genes frequently disrupted in diffuse large B cell lymphoma (1, 2).

Compared with the toxicity that we see with allogeneic donor hematopoietic stem cell therapy, these toxicities are relatively manageable with close monitoring and close supportive care.