Sentences with phrase «transcription factors»

It is critical that the pattern of transcription factor binding in the genome be maintained.

The research group has produced the most complete map yet of transcription factors in a cell.

The next generation of transcription factor binding site prediction.

Unlike most proteins, those with these special domains can actually bind to DNA and act as transcription factors — telling specific genes to turn on or off.

All of these genes code for transcription factors, which are proteins that control the expression of other genes.

Host proteins, including specific transcription factors with binding sites near transcription start sites, are necessary for this specificity (32 - 33).

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

This provides a comprehensive classification of human transcription factors based on their DNA - binding domains.

Another research field is the understanding of gene regulatory principles on the level of small - scale transcription factor networks.

To test how transcription factors interact during development, the researchers created mouse embryos that were missing one or two of the proteins.

Our bodies have about 1,600 known transcription factors at work within our genome.

A key concern, they noted, was the possible risk associated with using transcription factors that may themselves be linked to the early stages of leukemia.

Any conclusions regarding occupancy of a single strand of DNA by different transcription factors is based on inference.

She has published numerous original method manuscripts in this area, and is currently collaborating with hospital - based research groups and pharmaceutical companies worldwide studying transcription factors pathways in several diseases.

However, much like in a natural human language, the DNA words can be joined to form compound words that are read by multiple transcription factors.

When those same transcription factors land on another part of the code, the risk of multiple sclerosis appears to rise.

The regulators included proteins known as master regulator transcription factors.

The results in all three tests identified numerous relevant transcription factors in the top 20 hits — again, from a potential pool of more than 2,000 factors.

However, it's not easy to design small molecules against transcription factors — by their nature they don't have a molecular structure we can easily design blocking chemicals against.

By altering transcription factors, the entire regulatory network can change with very few mutations, increasing the impact and minimizing the risk.

Each type of transcription factor recognizes and binds to a certain sequence of DNA.

The kit is ideal for more difficult primary cell samples and for the enrichment of low abundant transcription factors.

This is the master regulator of insect development, and it was the first transcription factor ever discovered.

A short stretch of DNA that regulates gene expression by acting as a landing platform for regulatory proteins, e.g. transcription factors.

It is situated just next to a thyroid - specific transcription factor, a protein that regulates the rate of gene expression in the thyroid.

There are about 1,600 known human transcription factors that do their work along the human genome.

Using both computer modeling and laboratory experiments, they discovered that it was possible to enhance the production of individual components of the cell wall under certain stress conditions by regulating different transcription factors.

Next, the scientists created cardiac cells missing the same transcription factors to investigate how their interactions affect gene expression.

It does this by making sure that no relevant transcription factors are around to make RNA from the genes.

These discoveries come into a favorable context of new drugs against transcription factors being tested in clinical trials.

These include a family of signaling molecules called protocaderins, which regulate neuronal development and short - range interactions between neurons, and a family of transcription factors called zinc fingers, which are mainly expressed in embryonic and nervous tissues and are thought to play roles in brain development.

David (Monash University, Victoria, Australia) has uniquely influenced analysis of flower development, initially by contributing to development of the ABC model for flower development, and more recently by studying other transcription factor families involved in flower morphogenesis.

What's important about the discovery is that MER41's bits and pieces include binding sites for transcription factors involved in fighting infections.

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

, Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF - κB

In the past years, we focused our attention on Srf transcription factor which is one of the three master genes that controls myogenesis in Caenorhabditis elegans, together with MyoD and HAND.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

The stem cell transcription factor SOX2, which is critical for stem cells, cell reprogramming, and brain development, also is activated in astrocytes in the adult brain.

Immune cell functions are tightly regulated by essential transcription factors such as NF - κB and NFAT.

Knockdown of Nrf2 expression resulted in reduced induction of HMOX1 by HPP - 4382, CoPP and bardoxolone, consistent with the well - characterized role of Nrf2 as a critical activating transcription factor for HMOX1.

LLM - Domain B - GATA Transcription Factors Play Multifaceted Roles in Controlling Greening in Arabidopsis

Austin Smith of the Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute teamed up with investigators from the Microsoft Research Computational Science Laboratory, also in the U.K., to incorporate experimental data on 20 key transcription factors involved in stem cell self - renewal.

We then conducted a survey of transcription factors essential to the expression of RIG - G.

A diagram showing the expressed transcription factors, signaling molecules, and guidance factors

«There is emerging evidence that the FOXO transcription factor family plays a critical role in metabolic, antioxidant, and cell death responses in the liver.

Calling on transcription factors like NRF - 1 for damage control.