Sentences with phrase «cell expressing»

Living cells express genes involved in physiological functions like development and metabolism via complex mechanisms.

Agents of the immune system are constantly checking the surfaces of cells for chemical signals that say they belong, but cancer cells express the same chemical signals as healthy ones.

After 15 days, a subset of cells expressed regulators of RGC differentiation (Atoh7, Brn3b, and Islet1), while a smaller subset co-expressed Brn3b and the mature RGC marker Thy1, thus confirming a RGC identity.

ES cell chromatin is open at a global level [3], and the stem cells express high levels of chromatin remodeling factors.

Bone marrow stem cells express receptors for multiple adipokines, including the adipose - derived hormone leptin (9, 10).

Luciferase expression was markedly lower in cells expressing Bach1, indicating effective repression of HMOX1 E2 - dependent transcription by Bach1 (Figure 6B).

Kaplan - Meier analysis demonstrated that most of the mice injected with cells expressing wild - type PREX2 or GFP exhibited tumor - free survival for more than ten weeks.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Additionally, enhanced hiPS - HEP cells express genes involved in the urea cycle within the same range as hphep cells (Figure 3, Panel D), and the cells secrete albumin and urea (Figure 3, Panels E and F).

Here, we use a fluorescent reporter cell line that employs translational amplification to visualize single ES cells expressing low levels of lineage - specific genes.

Consequently, the resultant transgenic T cells express more of the cancer - specific TCR and are thus more efficient at targeting the cancer and a thousand-fold more sensitive to antigen expressed by the cancer.

Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.

Time - lapse movie of zebrafish lens epithelial cells expressing GFP - histones and mCherry - zGem as they progress through the cell cycle.

Computational classifiers trained between wild ‐ type cells and cells expressing Cas9 and gRNA enable the profiling of multivariate single cell phenotypes.

Here they have been infected by a herpes virus that carries a «brainbow cassette,» which makes cells express proteins that are tagged with a variety of fluorescent colors.

Perin also used antibodies to label cells expressing vimentin and desmin, proteins found on developing, not mature, heart muscle cells.

In another experiment, Kelsoe found that B cells expressing the rearrangement genes bound less tightly to an antigen than did B cells that didn't rearrange their DNA.

In parallel, we will investigate the accumulation and function of transcription coactivators, including the Mediator and different histone modifying enzymes, on endogenous sestrin genes in mouse cells expressing wild type versus serine18 mutant p53.

In the R5 - ZFN control group, with intact cxcr4 genes, 88 % of CD4 + T cells expressed CXCR4 protein at day 27 post engraftment, compared to 84 % of cells in the X4 - ZFN mice (∼ 24 % cxcr4 gene disruption) as determined by a fluorescence minus - one (FMO) control.

The collaborative research group, which included Dr. Eran Meshorer of the Department of Genetics at the Silberman Institute of Life Sciences at the Hebrew University of Jerusalem, has revealed that the embryonic stem (ES) cells express large proportions of their genome «promiscuously.»

Upon IL - 23 stimulation, ILCs isolated from untreated mice had a greater percentage of cells expressing IL - 22 than lethal toxin treated mice (Fig 6C).

Furthermore, pluripotency of the parental and edited cell populations was maintained, with nearly 100 % of cells expressing SSEA - 4 (assessed via flow cytometry in Panel B) and Oct ‑ 4 (assessed via immunohistochemistry in Panel C).

Roberts, E. W. and Deonarine, A. and Jones, J. O. and Denton, A. E. and Feig, C. and Lyons, S. K. and Espeli, M. and Kraman, M. and McKenna, B. and Wells, R. J. B. and Zhao, Q. and Caballero, O. L. and Larder, R. and Coll, A. P. and O'Rahilly, S. and Brindle, K. M. and Teichmann, S. A. and Tuveson, D. A. and Fearon, D. T. (2013) Depletion of stromal cells expressing fibroblast activation protein - alpha from skeletal muscle and bone marrow results in cachexia and anemia.

Kraman, M. and Bambrough, P. J. and Arnold, J. N. and Roberts, E. W. and Magiera, L. and Jones, J. O. and Gopinathan, A. and Tuveson, D. A. and Fearon, D. T. (2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein - alpha.

For quantifying the performance of Amrose in deep tissue optical imaging experiments, DT40 cells expressing no FP (control), Amrose v1 and mRaspberry were used.

Actively regenerating tissues expressing a gene have mRNAs with shorter tails, while mature cells expressing that same gene have mRNAs with longer tails,» says Vairavan Lakshmanan, who is one of the lead authors of the paper that details these findings.

We only found cells expressing neural markers within the central zone, where many cells were negative for both pluripotency and lineage specific markers.

The fact that these stem cells express fewer metabolic genes might be one way to protect the cells from the daily grind faced by their peers, and to limit the production of metabolic byproducts that can damage DNA.

The livers of mice with T cells expressing LIGHT made and secreted much less hepatic lipase — and consequently, had higher plasma lipid levels.

A single mammalian cell expressing a mutant green fluorescent protein is the first living object to be used as a laser

They developed a fluorescent tag that could find and identify cells expressing a gene called ALPL.

In the new study, Chen and colleagues tried to figure out if cells expressing GRPR were the long - sought itch - only neurons.

This time, researchers modified T cells to attack cancer cells expressing NY - ESO - 1, an antigen found in nearly 60 percent of multiple myelomas and previously shown to be associated with tumor growth and poor prognosis.

(A) Venus positive cells express Oct4, but not Nanog.

Neuronal cells express a pp60c - src variant that displays an altered electrophoretic mobility and a different V8 peptide pattern relative to pp60c - src expressed in tissues of non-neuronal origin.

(G) Cells expressing YFP (green) co-express the cone photoreceptor (cPR) marker Calbindin (yellow).

Human corneal endothelial cells expressed both p53 and TAp63; expression was greater in the central endothelium than in the peripheral endothelium (Figure 2).