Sentences with phrase «tumour cells»

In collaboration with Dr Gabriele Bonatz from the Augusta clinics in Bochum (Brustzentrum), Hatt's team confirmed the existence of TRPV1 in tumour cells in nine different samples from patients suffering from breast cancer.

In the genome of tumour cells of 11 patients, the scientists observed the insertion of a viral DNA segment from adeno - associated virus type 2, known as AAV2.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

These results were facilitated by the permanent cultivation of circulating tumour cells of patients with advanced SCLC in Vienna.

Cancer arises from the transformation of normal cells into tumour cells in a multistage process that generally progresses from a pre-cancerous lesion to a malignant tumour.

Throughout my research career as a translational clinician - scientist I have had an abiding interest in the mechanisms of tumour cell growth, and the development of innovative strategies to improve diagnosis and therapy for cancer patients.

The researchers concluded that patients with circulating tumour cells with more N - terminals than C - terminals had the androgen receptor variants.

Other safety strategies include improving the specificity of CAR T - cells for tumour cells because healthy cells also carry CD - 19 receptors.

For cancer, he hopes to adopt a similar approach in which the transplanted nodes will contain T cells trained to hunt down the antigens produced by tumour cells and kill them off.

The Journal of Agricultural and Food Chemistry had on its December 2006 issue a report that found the ability of red raspberries to repress the human oral and breast, as well as colon and prostate tumour cell lines growths when they were tested in test tubes.

Most of the studies have focused mainly on tumour cells, whilst the cells that form the stroma are the great unknown, in spite of different research groups proving that some components of stroma promote the tumour progression.

Around 15 per cent of women with breast cancer have this form of the disease, in which tumour cells lack the three receptors that most drugs target.

This will help to uncover how tumour cells communicate with the healthy cells around them and test new drugs in a more realistic way without involving animals.

Even if you get most of the brain tumour out it comes back again, so we were wondering if you could leave something in the brain cavity that would help target chemotherapy precisely to the tumour to destroy the remaining tumour cells responsible for the disease coming back.

The drugs used in chemotherapy prevent tumour cells from dividing, so they stop growing or die in a variety of ways.

In the case of cancer, ineffective cell adhesion allows tumour cells to detach and invade other tissues, thereby spreading cancer throughout the body.

Researchers used tumour cells derived from 100 different glioblastoma patients to test drugs that could target the disease.

Because tumour cells are more dependent than their normal neighbours on accelerated nutrient import, these up - regulated transporters could be excellent targets for selective anti-cancer therapies.

A study published a couple of years ago, for example, showed that «chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape.»

In the second part of their work, they used primary tumour cells taken directly from 27 patients, the scientists again identified the same cytokines.

«Tumour cells often take advantage of existing mechanisms, such as the one we have described, to cause havoc.

The researchers, working with cell cultures, first observed how individual tumour cells kill specific cells in the vascular wall, called endothelial cells.

When tumour cells spread, they first enter the blood stream and grip onto the inner walls of blood vessels.

This suggests that the presence of AR - V7 in circulating tumour cells does not preclude response to galeterone as has been shown to be the case for abiraterone and enzalutamide.»

He is studying how autophagy promotes tumour cell survival and studying whether these pathways can be used as novel targets for T cell therapy.

This makes it much easier to find out who they bind to, where they are localised, and what their levels of expression are — all in the patient derived tumour cells.

The analysis revealed that the Saa3 gene is responsible for CAFs helping tumour cells to progress.

This bank of living tumour cells allowed the team to study not only the genetics of the cells, but also how genetic mutations in the mitochondria — which drive energy production in the cell — caused changes in the cell's metabolism.

Initially, the Geneva researchers observed the vascularisation processes of human tumour cells from different cell lines.

Cashews are full of proanthocyanidins, a class of flavonols which fight against cancer tumour cells by preventing them from dividing any further.

Detecting «sleeper cells»: drug - tolerant cells (without a coloured nucleus) can be distinguished from active, dividing tumour cells (red or green nuclei) using new markers.

Richard Lehner, professor of Pediatrics and investigator at the University of Alberta's Faculty of Medicine & Dentistry, has taken his research further to understand how tumour cells grow through scavenging very low - density lipoproteins (VLDL) and low - density lipoproteins (LDL), commonly known as the «bad cholesterol,» and what mechanisms can be used to reduce the malignant cells» growth.

«This tumour is so aggressive and so complex that it is necessary to try and attack it from various sources, not only tumour cells.

Targeting tumour cell metabolism represents a novel and exciting approach, and we are delighted to be working with The University of Manchester and Cancer Research UK to investigate the utility of AZD 3965 as a potential novel cancer treatment.»

When breast tumour cells develop in reaction to MPA, they promote the formation of new blood vessels inside tumours, which then supply necessary nutrients for the growth and multiplication of tumours.

Tumour cells need an increased supply of amino acids to support protein and nucleotide synthesis.

Men whose tumour cells exhibited low glycolysis survived an average of 9 1/2 years, whereas those with high - glycolysis tumours survived for only six years on average.

Most tumour cells spread via the bloodstream.

This review explores the mechanistic basis of tumour cell invasion by focusing on the reorganisation of the dendritic actin network.

However, tumour cells develop strategies for resisting these drugs, most commonly to produce more of a particular protein or enzyme able to repair the DNA damage caused by the chemotherapy.

She has worked in prestigious Institutions like the NIH - NCI, Bethesda, Md and the MIT, Cambridge, MA and developed an internationally recognised research profile in tumour cell migration and invasion with over 65 publications and 2 patents to her name.

Finding tumour cells in the blood indicates a cancer has metastasised — but the molecular markers that are used to identify the cells can modify them and make them unsuitable for study to confirm metastasis.

«This looks like very clever technology which can specifically target and destroy tumour cells in this animal work.

This was reported by a team headed by the Bochum - based scent researcher Prof Dr Dr Dr habil Hanns Hatt and Dr Lea Weber, following experiments in cultivated tumour cells.

Researchers at Hokkaido University in Japan have demonstrated that a molecule, called biglycan, plays an intrinsic role in attracting tumour cells toward the inner wall of tumour blood vessels.