Sentences with word «telomeres»
Telomeres are protective caps that exist at the ends of our DNA strands. They act like the plastic tips at the end of shoelaces, preventing the DNA from fraying or sticking together. They are important for cell division and play a role in the aging process. Full definition
«The slower pace of telomere shortening found in the study participants who have more children however, may be attributed to the dramatic increase in estrogen, a hormone produced during pregnancy,» says Nepomnaschy who also spearheads the Maternal and Child Health Laboratory at the SFU Faculty of Health Sciences.
sciencedaily.com
According to a study carried out at the University of California at San Francisco, drinking 20 ounces of sugar - sweetened soft drinks daily was associated with telomere shortening in humans.
Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood
The researchers sought to measure the length of telomeres in three groups of people.
But do longer telomeres mean longer life in normal circumstances?
Telomerase lengthens telomeres by repeatedly synthesizing very short DNA repeats of six nucleotides — the building blocks of DNA — with the sequence «GGTTAG» onto the chromosome ends from an RNA template located within the enzyme itself.
«Does starvation exert a stronger effect on telomere length in the reproductive cells of adults than in the leukocytes of children?
However, this treatment would require long treatment periods, as telomeres shorten by small steps over several cell divisions.
Most of your studies look at telomere length in white - blood cells, but you've started looking at cells in saliva.
«We also found an association between telomere shortening and thiamine deficiency (TD),» said Yamaki.
The shorter telomeres get, the more likely cells are to die.
Now, in a move that brings these questions into sharper focus for the general public, Telome Health, founded by Elizabeth Blackburn, who won the Nobel for Medicine for her work in this area, has announced that it will bring to market a test for telomere length.
The cells die when telomeres become too short and this increases the aging process.
Further understanding of the DNA damage checkpoints induced by telomere dysfunction during aging will lend support to develop therapeutic approaches to slow down aging process and improve old organ functions.
U. Biswas, M. Stevense, and R. Jessberger SMC1α Substitutes for Many Meiotic Functions of SMC1β but Can not Protect Telomeres from Damage.
When telomeres become shortened, we are more susceptible to disease such as cancer, diabetes and heart disease.
They hope to learn more about the relationship between the birds» immune systems and an enzyme called telomerase, which maintains telomere length, extending the chromosome's ability to replicate.
The team observed a relative scarcity of nucleosomes at telomeres from ASF1 - depleted cells, as one might expect once a histone chaperone is lost.
One study demonstrated that mitochondrial DNA loss dictates rate of telomere loss and MLSP.
Nevertheless, it provides initial evidence for the association of telomere G - tail length with aging, endothelial function, and ARWMCs in patients with vascular risk factors.
She co-founded a company called Life Length, which measures telomeres for patients, companies, and researchers.
Autoimmune Diseases Adrenal Fatigue Body Composition Carotid Ultrasound w / CIMT Comprehensive Lab Testing DEXA Scan Dysautonomia Fibromyalgia Food Sensitivity Testing GAINSWave ™ ED Treatment Gluten Sensitivity Testing Medical Biofeedback Micronutrient Testing Neurocognitive Testing Overtraining Syndrome Prostate Cancer Resting Metabolic Rate Test Telomere Testing Traumatic Brain Injury VENDYS Vascular Test VO2 Max Testing
By keeping telomeres long, ATRX mutations give cells the ability to endlessly divide, a hallmark of cancer.
Yamaki added that it's important for the public to understand that heavy drinking causes telomere shortening because «awareness of this fact provides important information necessary for people to live healthier.»
Austad recalls one conversation in which Muller made an insightful connection about telomeres, the DNA - and - protein caps at the ends of chromosomes that shorten with every cell division, eventually pushing cells into a nondividing state called senescence.
Greider pointed out in her paper that longer telomeres do not correlate with greater longevity in animals.
The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators.
Because telomere length influences premature aging and cancer, Yildiz's findings bear long - term therapeutic implications.
Gottschling and his graduate student Miriam Singer devised a way to hunt for mutations in genes that must somehow be involved with telomere function in yeast.
Scientifically speaking, there's a lot riding on telomere research, from ageing and cancer prevention to the future of cloning.
If telomeres get too short, the cell can no longer divide and becomes inactive or dies.
«Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes.
James Christiansen, professor of biology at Drake University in DesMoines, is studying how telomeres, the simple, non-genetic DNAsequences that sheathe the ends of chromosomes, function in reptiles.Each time a healthy human cell divides, it loses a little bit of thetelomere, until the strands are too short to protect the chromosomes.At that point the DNA in a cell begins to break down, which triggerssenescence and death.
Intrigued, after finishing her Ph.D. in 1983, she decided to study telomeres as a postdoc with Harvard Medical School chromosome biologist Jack Szostak.
It also means that the role of telomere biology at a very early step of cancer development is vastly underappreciated,» said senior author Dirk Hockemeyer, a UC Berkeley assistant professor of molecular and cell biology.
«Such a relationship between leukocyte telomere length and physical activity level remained significant after adjustment for body mass index, smoking, socioeconomic status and physical activity at work,» the authors report.
Previous work published by Samani has linked telomere shortening with heart disease, suggesting that biological age may be more relevant to age - related diseases than chronological age.
The study, published in the Journal of Investigative Dermatology measured the length of white blood cell telomeres in 1,205 twins from the TwinsUK cohort.
The secret to higher HGH levels and longer life may be in telomeres found at the ends of our chromosomes.
The idea that shrinking telomeres play a role in organismal aging had been hyped in the media and by Geron's public relations division, she says.
This process ultimately helps to maintain the protective structure that prevents fusion of chromosomes or the slow erosion of telomere DNA.
Cells in sperm, bone marrow, and other tissues that divide frequently make an enzyme called telomerase that prevents telomeres from shrinking.
Exercise is just one of many lifestyle factors that preserve telomere length and thus slow the aging process.
Using genome data from more than 50,000 cancer cases and 60,000 controls through the GAME - ON (Genetic Associations and Mechanisms in Oncology) network, the team compared telomere lengths with the risk of developing breast, lung, colorectal, ovarian and prostate cancers, including subtypes.