Sentences with word «zebrafish»

We will use the power of modeling tumors in zebrafish in combination with patient derived cell lines and tumors and murine xenograft models to define tumor heterogeneity.

Intriguingly, abnormal muscle contractions are also observed in muscular dystrophy patients and they were previously reported in zebrafish embryos with a related genetic defect, Panin said.

Developing zebrafish models of complex phenotypes relevant to human brain disorders.

This approach opens new avenues for research into memory using zebrafish as model organism,» concludes Dr. Okamoto.

13:30 - 13:50 Svante Winberg, Uppsala University, Dept. of Neuroscience Zebrafish as a model in studies on animal behavior

More over, an experimental set - up for optical transfer of behaviour between different subjects is being developed in zebrafish larvae, performing whole - brain real - time mapping of neuronal calcium dynamics in virtual - reality controlled visual and sensory experience.

For the study, the researchers created a line of zebrafish with defective immune systems by inserting a mutation into a gene required for development of an important component of the immune system.

In a study by Junker et al, the authors studied zebrafish embryos at the 15 somites stage by straightening them, then segmenting them into about 100 slices, each roughly 18 µm thick.

In the Cheng lab, the candidate genes and mutations can then be tested in zebrafish for verification.

In the team's studies on zebrafish embryos, the embryos responded to a magnetic field by twirling, which they generally do in response to pressures in the water.

To identify the molecular mechanisms of neural stem cell plasticity in adult zebrafish brain after various types of tissue damage or physiological stimulations

To track and measure blood flow in developing zebrafish hearts, bioengineer Jay Hove of the California Institute of Technology in Pasadena and his colleagues borrowed tricks from genetics and engineering.

A novel drug screening platform for zebrafish brain tumors was then designed to identify drugs that could eliminate brain tumors without affecting development of the normal brain.

This information would then be added into the core Ensembl gene - set (the reference zebrafish genome used by researchers around the world) in such a way as to increase the quantity and quality of the gene - set without adding artifacts or pseudogenes.

However, to be able to do this, we need to have as complete as a list of zebrafish genes as possible.

Western blotting of phospho - Smad1 / 5/8 from zebrafish embryo extracts was previously described (35).

A genome wide transcriptome dataset of the embryonic zebrafish heart with high spatial resolution was established and used to identify a novel mechanism regulating pacemaker function.

«Thus, we hypothesize that Gdf3 combines with Ndr1 and Ndr2 to facilitate Nodal signaling during zebrafish development, acting as an essential factor in embryonic patterning,» said Pelliccia, a graduate student in molecular biology.

The effects of paclitaxel, a chemotherapy drug, can be seen on the cellular structures of the skin of a larval zebrafish tail fin.

Researchers tracking down the cause of anemia in mutant zebrafish embryos have discovered a protein that guides the creation of new blood cells.

In addition to Wingert, authors include Poureetezadi, Christina N. Cheng, Joseph M. Chambers and Bridgette E. Drummond, graduate students in her laboratory, the Center for Stem Cells and Regenerative Medicine and the Center for Zebrafish Research.

Eager to utilize my newfound technical skills at the bench, I contacted a recently appointed junior professor in the biochemistry department at the University of California, San Francisco (UCSF), who was setting up a new zebrafish facility.

Mark T. Keating and his colleagues at Harvard Medical School wounded the hearts of adult zebrafishes by surgically removing 20 percent of the muscle from the lower chamber.

When the scientists inserted human colorectal cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of human solid tumors: rapid cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the body.

At the same time as Burdine and colleagues, two other research groups, led by Joe Yost at the University of Utah and Alex Schier at Harvard University, made similar findings on the role of gdf3 during zebrafish development.

Here you can find out more about our video protocol on using light sheet microscopy to image zebrafish eye development.

As a postdoctoral fellow at the University of Washington she developed a method to image and track cell migration in live zebrafish embryonic tissue explants.

Sarah Hochmann (Brand, TUD)-- «The role of Fgf signaling in photoreceptor maintenance and degeneration in the adult zebrafish retina» (2011)

He and his colleagues decided to study how zebrafish regenerate tissue, looking for ways to activate this process in humans.

The researchers reported in 2008 that the embryonic zebrafish brain is patrolled by about 20 of the cells.

Earlier this year, Peterson and his collaborator, neuroscientist Alex Schier of Harvard University in Cambridge, Mass., published the first two small - molecule screens based on zebrafish behavior.

The shared gene allows zebrafish to sense water flow direction, and it also helps cells inside the human ear sense a range of sounds.

To investigate how zebrafish tails take shape, Thisse's team removed some of the presumed pre-tail cells from early - stage embryos, then transplanted them into the middle of another embryo.

Cocaine distribution in five - day - old zebrafish larvae exposed to 50 µM cocaine for eight hours.

A new study of the University of Barcelona, published in the journal Human Molecular Genetics, first describes a phenotype of this human disease through the study of genetically - modified zebrafish models.

To investigate, Peterson's team exposed zebrafish embryos to thousands of drugs and recorded how each affected their reaction to a flash of light or a slight poke (Nature Chemical Biology, DOI: 10.1038 / nchembio.307).

Conditioned zebrafish treated with naloxone, a drug that blocks the μ - opioid receptor, as well as dopamine - or glutamate - blockers reduced their drug - seeking behavior during the experiments.

Live imaging of the lymphatic vascular network using transgenic zebrafish Hyun Min Jung, NICHD / NIH

Notch signaling coordinates cellular proliferation with differentiation during zebrafish fin regeneration.

The research team previously noticed that male zebrafish regenerate their pectoral fins poorly, as compared to females.

«Microbial dispersal impacts animal guts: Study with zebrafish finds that transmitted microbes will lead to similar microbiomes and a selection process for some microbes.»

Drawing upon the cell culture expertise of Noriyoshi Sakai, Ph.D., and Kayoko Kurita, of Fukui Prefectural University, the Japanese - U.S. team developed a system that enables immature sperm cells, or spermatagonia, taken from male zebrafish to survive long enough in vitro that they can receive foreign genes inserted by a retrovirus.

When zebrafish with the green fluorescing endothelial gene matured, the researchers observed green FGPs on the surface of the fish's brains — confirming that these cells arose from endothelial tissue.

In analyses of 23 videos of five different types of animals (mice, fruit flies, ants, zebrafish [shown], and small tropical fish called medaka), the software was able to identify and correctly track individuals (color - coded trails) within those groups 99.7 % of the time, researchers report online today in Nature Methods.

Recent studies on species such as zebrafish showed scales and teeth developing from distinctly different clusters of cells in fish embryos, pouring cold water on «teeth from scales» theories.

A recent study by Duke University uncovered the genes that help zebrafish repair damaged tissue.